82053-95-0

Basic information

• Product Name: 5-(2-Methoxy-3-methyl-phenyl)-6-methyl-heptan-3-ol
• CAS NO: 82053-95-0
• Molecular Weight: 250.381
• Mol File: 82053-95-0.mol

Chemical Properties

• CAS DataBase Reference: 5-(2-Methoxy-3-methyl-phenyl)-6-methyl-heptan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Methoxy-3-methyl-phenyl)-6-methyl-heptan-3-ol(82053-95-0)
• EPA Substance Registry System: 5-(2-Methoxy-3-methyl-phenyl)-6-methyl-heptan-3-ol(82053-95-0)

Safety Data

• Hazardous Substances Data: 82053-95-0(Hazardous Substances Data)

Upstream product

• 82053-90-5 2'-methoxy-3'-methylisobutyrophenone 
• 82053-94-9 5-(2'-methoxy-3'-methylphenyl)-6-methylheptan-3-one 
• 82054-01-1 3-(2-Methoxy-3-methyl-phenyl)-4-methyl-pent-3-enoic acid ethyl ester 
• 82054-00-0 (Z)-3-(2-Methoxy-3-methyl-phenyl)-4-methyl-pent-2-enoic acid ethyl ester 
• 82053-92-7 3-(2'-methoxy-3'-methylphenyl)-4-methylpentanoic acid 

Downstream Products

• 55012-72-1 5-hydroxycalamenene 

Relevant articles and documents

Studies in Terpenoids: Part LV - Synthesis of 5-Hydroxycalamenene, a Phenolic Sesquiterpene from Bazzania tricrenata

Fries rearrangement of o-cresyl isobutyrate (IV) gives the o-hydroxyketone (V).Dehydration and saponification of the Reformatsky reaction product of the methoxyketone (VI) with ethyl bromoacetate affords the unsaturated acid mixture (VII).The saturated aryl methylpentanoic acid (VIII) derived from VII is reacted with ethyllithium to give the ketone (IX).The secondary alcohol (X) obtained from IX is cyclodehydrated and demethylated in one step to give 5-hydroxycalamenene (I) which is produced stepwise also from X via the methoxytetralin (XI) obtained by PPA treatment.