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"Z3-Arg-Pro-t-Bu" is a synthetic peptide consisting of three amino acids: N-benzyloxycarbonyl (Z) protected arginine (Arg), proline (Pro), and tert-butyloxycarbonyl (t-Bu) protected arginine (Arg). This peptide is often used in biochemical research and drug development due to its specific sequence and protective groups, which can influence its stability, reactivity, and interaction with other molecules. The Z and t-Bu groups are commonly used protecting groups in peptide synthesis to prevent unwanted side reactions and to control the peptide's reactivity until the desired point in the synthesis process. The sequence Arg-Pro-Arg is significant as it can mimic certain natural peptide sequences, potentially affecting biological activity or serving as a substrate for specific enzymes.

82068-75-5

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82068-75-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 82068-75-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,0,6 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 82068-75:
(7*8)+(6*2)+(5*0)+(4*6)+(3*8)+(2*7)+(1*5)=135
135 % 10 = 5
So 82068-75-5 is a valid CAS Registry Number.

82068-75-5Upstream product

82068-75-5Relevant academic research and scientific papers

Stabilized analogs of thymopentin. 2. 1,2- and 3,4-ketomethylene pseudopeptides

DeGraw, Joseph I.,Almquist, Ronald G.,Hiebert, Charles K.,Judd, Amrit K.,Dousman, Linda,Smith, R. Lane,Waud, William R.,Uchida, Itsuo

, p. 2398 - 2406 (2007/10/03)

In this second paper in a series of three studies of stable analogs of thymopentin (Arg1-Lys2-Asp3-Val4-Tyr5), the synthesis of analogs stablized at peptide bonds 1,2 and 3,4 via insertion of ketomethylene units is described. A tris(carbobenzyloxy)arginyl(k)norleucine pseudopeptide was synthesized and coupled to Asp-Val-Phe-resin units followed by HF cleavage to prepare Arg(k)Nle-Asp-Val-Phe analogs. Preparation of N-BOC Asp(k)Val and N- BOC Asp(k)Ala units followed by coupling to Phe- or Tyr-resin units provided resin-bound pseudotripeptide substrates for attachment of various arginyl dipeptides. Cleavage from the resin afforded 3,4-ketomethylene-stabilized pseudopeptide analogs of thymopentin. The Arg-Lys-Asp(k)Val-Phe and ArgLys- Asp(k)Val-Tyr analogs were more strongly bound to CEM cells than thymopentin itself. There was significant enhancement of stability in serum for the analogs, especially those containing Arg(k)Nle or Arg-NMeLys moieties at the 1,2-peptide bond.

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