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82072-22-8

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82072-22-8 Usage

General Description

(3-(Bromomethyl)phenyl)methanol is a chemical compound with the molecular formula C8H9BrO. It is a white to off-white solid that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is primarily used as a reagent in the preparation of various types of organic compounds through its reactions with different functional groups. (3-(BROMOMETHYL)PHENYL)METHANOL is also known for its potential applications in the fields of medicinal and material chemistry due to its unique chemical reactivity and structure. However, it is important to handle and use this compound with caution, as it is a brominated organic compound and may pose health and environmental risks if not properly managed.

Check Digit Verification of cas no

The CAS Registry Mumber 82072-22-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,0,7 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 82072-22:
(7*8)+(6*2)+(5*0)+(4*7)+(3*2)+(2*2)+(1*2)=108
108 % 10 = 8
So 82072-22-8 is a valid CAS Registry Number.

82072-22-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name [3-(bromomethyl)phenyl]methanol

1.2 Other means of identification

Product number -
Other names 3-Bromomethylbenzyl alcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:82072-22-8 SDS

82072-22-8Relevant articles and documents

Galantamine-curcumin hybrids as dual-site binding acetylcholinesterase inhibitors

Atanasova, Mariyana,Atanasova, Teodora,Doytchinova, Irini,Ivanov, Stefan,Konstantinov, Spiro,Lukarski, Atanas,Philipova, Irena,Stavrakov, Georgi,Zheleva, Dimitrina,Zhivkova, Zvetanka D.

supporting information, (2020/08/06)

Galantamine (GAL) and curcumin (CU) are alkaloids used to improve symptomatically neurodegenerative conditions like Alzheimer's disease (AD). GAL acts mainly as an inhibitor of the enzyme acetylcholinesterase (AChE). CU binds to amyloid-beta (Aβ) oligomers and inhibits the formation of Aβ plaques. Here, we combine GAL core with CU fragments and design a combinatorial library of GAL-CU hybrids as dual-site binding AChE inhibitors. The designed hybrids are screened for optimal ADME properties and BBB permeability and docked on AChE. The 14 best performing compounds are synthesized and tested in vitro for neurotoxicity and anti-AChE activity. Five of them are less toxic than GAL and CU and show activities between 41 and 186 times higher than GAL.

Aromatic PCN palladium pincer complexes. Probing the hemilability through reactions with nucleophiles

Fleckhaus, André,Mousa, Abdelrazek H.,Lawal, Nasir Sallau,Kazemifar, Nitsa Kiriakidou,Wendt, Ola F.

, p. 1627 - 1634 (2015/05/20)

A series of unsymmetrical PCN pincer ligands (1-(3-((di-tert-butylphosphino)methyl)phenyl)-N,N-dialkylmethanamine) were cyclometalated with palladium to generate a series of new PCN supported Pd(II) chloro complexes, (PCN)PdCl (4-6), where alkyl = methyl, ethyl, and n-propyl, which were fully characterized by NMR spectroscopy and X-ray crystallography. The N,N-dimethyl complex 4 reacts with methyl lithium to give the corresponding methyl and dimethyl complexes (PCN)PdMe (12) and Li[(PCN)PdMe2] (13), which could not be isolated but were characterized in solution. The substitution reactions of (PCN)PdCl (4-6) with iodide to form the corresponding iodo complexes (PCN)PdI (7-9) were investigated by use of UV-vis stopped-flow spectrophotometry. The experiments were performed in methanol over a temperature range from 293 to 325 K. The reactions are reversible and were shown to proceed exclusively via the solvento complex in two reversible consecutive steps. Activation parameters for both the forward and reverse reactions were determined, and they, together with reactivity trends, support an associative pathway. No displacement of the nitrogen donor was detected, and overall this points to a limited hemilability of the ligands on palladium.

PIPERIDINE-DIONE DERIVATIVES

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Page/Page column 106, (2015/11/10)

The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

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