82079-94-5

Upstream product

• 82053-90-5 2'-methoxy-3'-methylisobutyrophenone 
• 128291-80-5 1-(2-methoxy-3-methylphenyl)-2-methyl-1-propanol 
• 128291-91-8 1-iodo-1-(2-methoxy-3-methylphenyl)-2-methylpropane 
• 118304-45-3 1-hydroxy-8-isopropyl-5-methylnaphthalene-2-carbaldehyde 
• 128291-92-9 Toluene-4-sulfonic acid 3-(2-methoxy-3-methyl-phenyl)-4-methyl-pentyl ester 
• 128291-81-6 ethyl 2-cyano-3-(2-methoxy-3-methylphenyl)-4-methylpentanoate 
• 128291-82-7 2-carbamoyl-3-(2-methoxy-3-methylphenyl)-4-methylpentanoic acid 
• 128291-87-2 4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide 
• 128291-83-8 3-(2-methoxy-3-methylphenyl)-4-methylpentanamide 
• 82053-93-8 3-(2-methoxy-3-methylphenyl)-4-methylpentanoic acid 
• 128291-86-1 4-(2-methoxy-3-methylphenyl)-5-methylhexanenitrile 
• 128291-89-4 3,4-dihydro-5-methoxycadalene 
• 128291-88-3 3,4-dihydro-4-isopropyl-5-methoxy-6-methyl-1(2H)-naphthalenone 
• 128291-85-0 3-(2-methoxy-3-methylphenyl)-4-methyl-1-pentanol 

Relevant academic research and scientific papers

Studies on aromatic sesquiterpenes. XII. Synthesis of (±)-cis-5-Hydroxycalamenene

Starting from o-cresol, (±)-cis-5-hydroxycalamenene was synthesized through 4-isopropyl-5-methoxy-6-methyl-1-tetralone as a key intermediate and identified with the natural compound spectroscopically.

Total synthesis of (±)-cis-5-hydroxycalamenene

A total synthesis of (±)-cis-5-hydroxycalamenene 1 has been achieved from tetralone 5, which in turn was prepared from 5-methoxy-α-tetralone 3. Grignard reaction of compound 5 with isopropylmagnesium chloride, followed by dehydration and aromatization, provided the substituted naphthalene 7 whose conversion to (±)-cis-5-hydroxycalamenene 1 was accomplished by demethylation, formylation, and hydrogenation. Copyright Taylor & Francis Group, LLC.