82085-90-3Relevant academic research and scientific papers
CuCl/DABCO/4-HO-TEMPO-catalyzed aerobic oxidative synthesis of 2-substituted quinazolines and 4 H -3,1-benzoxazines
Han, Bing,Yang, Xiu-Long,Wang, Chao,Bai, Yong-Wei,Pan, Tai-Chao,Chen, Xin,Yu, Wei
experimental part, p. 1136 - 1142 (2012/02/16)
The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles. As demonstrated, 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2-aminobenzyl alcohols, respectively, by employing CuCl/DABCO/4-HO-TEMPO as the catalysts and oxygen as the terminal oxidant.
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: A novel series of 5-HT2A/2C receptor antagonists. Part 2
Ignacio Andres,Alcazar, Jesus,Alonso, Jose M.,Diaz, Adolfo,Fernandez, Javier,Gil, Pilar,Iturrino, Laura,Matesanz, Encarna,Meert, Theo F.,Megens, Anton,Sipido, Victor K.
, p. 249 - 253 (2007/10/03)
Following the programme started at Janssen Research Foundation searching for 5-HT2A/2C antagonists, we now report on the synthesis of a series of substituted 2-(Dimethylaminomethyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a] azepine derivatives. The 5-HT2A, 5-HT2C and H1 receptor affinities as well as the mCPP antagonistic activity of the compounds synthesised is described.
Ring-Chain Tautomerism in 1,3-Oxazines
Fueloep, Ferenc,Pihlaja, Kalevi,Mattinen, Jorma,Bernath, Gabor
, p. 3821 - 3825 (2007/10/02)
A comparative study on the ring-chain tautomerism of 49 2-(substituted-phenyl) tetrahydro-1,3-oxazines of seven different types, namely, tetrahydro-1,3-oxazines 3,r-8a,c-2,c-4a- and r-8a,c-2,t-4a-1,3-perhydrobenzoxazines 5 and 7,r-8a,c-2,c-4- and r-8a,c-2,t-4a-1,3-perhydrobenzoxazines 9 and 11, 3,4-dihydro-2H-1,3-benzoxazines 12, and 1,2-dihydro-4H-3,1-benzoxazines 13, pointed out that in all cases the equilibria can be described with a simple equation, log Kx = (0.76 +/- 0.04)?+ + logKX=H where Kx = /(X/H).A factor c illustrating the sum of ster ic and electronic effects of substituents at C-4,C-5, and C-6 has also been introduced
Effect of p-Substitution on the Spectroscopic Properties of 1,2-Dihydro-4H-2-phenyl-3,1-benzoxazines
Saeed, Ali A. H.
, p. 113 - 115 (2007/10/02)
A series of 1,2-dihydro-4H-2-phenyl-3,1-benzoxazines (I) were obtained by condensation of o-aminobenzyl alcohol and substituted benzaldehyde.The effect of p-substitution on their spectroscopic properties was investigated by uv and mass spectroscopy.
