82090-63-9Relevant academic research and scientific papers
Synthesis of New Condensed Pyrimidine Systems: Reactions of Heterocyclic Amines with Acetylenic Esters
Sahu, J. K.,Dehuri, S. N.,Naik, S.,Nayak, A.
, p. 117 - 120 (2007/10/02)
Several hitherto unreported 1,3,4-oxa/thiadiazolopyrimidin-7-ones (1 and 2) and thiazolopyrimidin-7-ones (3) have been synthesised by the reaction of 2-amino-1,3,4-oxa/thiadiazoles and 2-amino-4-arylthiazoles respectively with ethyl phenylpropiolate.The reaction of these amines with diethyl acetylenedicarboxylate furnishes the 7-oxo-5-carbethoxy derivatives (8-10).A similar reaction of 2-aminobenzothiazole with diethyl acetylenedicarboxylate affords 4-carbethoxypyrimidobenzothiazol-2(H)-one (7).To assign the structures of the 7-oxo derivatives the isomeric 5-oxo-7-carbethoxy derivatives (14) have also been synthesised by an unambiguous route.
SINTESI ED ATTIVITA ANTIMICOTICA DI DERIVATI DELL'1,3,4-TIADIAZOLOPIRIMIDONE
Russo, F.,Santagati, M.,Santagati, A.,Blandino, G.
, p. 983 - 993 (2007/10/02)
As a continuation of previous research designed to obtain derivatives of 1,3,4-thiadiazole of pharmacological interest, some derivatives of 1,3,4-thiadiazolepyrimidin-5-one and isomeric 7-one were prepared.The fungistatic activity of the products was tested in vitro against the following: Candida albicans, Candida parapsilosis, Candida tropicalis, Cryptococcus neoformans and Trichophyton rubrum.No relevant antifungal activity was observed for any of the compounds examined.
