820967-59-7Relevant academic research and scientific papers
A chiral base desymmetrisation - Ring-closing metathesis route to chiral azaspirocycles: Synthesis of core structures related to pinnaic acid and halichlorine
Huxford, Timothy,Simpkins, Nigel S.
, p. 2295 - 2298 (2007/10/03)
A range of highly functionalised chiral azaspirocycles was synthesised, starting from a piperidine diester that is available in 90% ee from a chiral base desymmetrisation. The approach depends upon the use of Grignard addition reactions or a Claisen rearr
