82098-68-8

Basic information

• Product Name: N-Benzyl-4-(4-cyano-phenyl)-2-(toluene-4-sulfonylamino)-butyramide
• Synonyms: N-Benzyl-4-(4-cyano-phenyl)-2-(toluene-4-sulfonylamino)-butyramide
• CAS NO: 82098-68-8
• Molecular Weight: 447.558
• Mol File: 82098-68-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Benzyl-4-(4-cyano-phenyl)-2-(toluene-4-sulfonylamino)-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-4-(4-cyano-phenyl)-2-(toluene-4-sulfonylamino)-butyramide(82098-68-8)
• EPA Substance Registry System: N-Benzyl-4-(4-cyano-phenyl)-2-(toluene-4-sulfonylamino)-butyramide(82098-68-8)

Safety Data

• Hazardous Substances Data: 82098-68-8(Hazardous Substances Data)

Upstream product

• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 82098-50-8 β-(4-Cyanphenyl)ethylacetaminomalonsaeurediethylester 
• 69395-13-7 4-(2-hydroxyethyl)benzonitrile 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 72054-56-9 4-(2-bromoethyl)benzonitrile 
• 82098-60-0 4-(4-Cyano-phenyl)-2-(toluene-4-sulfonylamino)-butyryl chloride 
• 100-46-9 benzylamine 

Downstream Products

• 82099-10-3 4-[3-Benzylcarbamoyl-3-(toluene-4-sulfonylamino)-propyl]-thiobenzimidic acid methyl ester; hydriodide 
• 82099-31-8 N-Benzyl-4-(4-carbamimidoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide; hydriodide 
• 82098-89-3 N-Benzyl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide 

Relevant articles and documents

Synthesis of 4-(4-Amidinophenyl)-2-arylsulphonylaminobutyric Acid Amides

4-(4-Amidinophenyl)-2-arylsulphonylaminobutyric acid amides with differing amide and arylsulphonyl components were synthetized to test their inhibitory activity against serine proteinases.For the purpose of preparing these compounds, β-(4-cyanophenyl)ethylbromide (5) was reacted with acetaminomalonic acid diethyl ester to give 6, the acid hydrolysis of which yielded predominantly 4-(4-carbamoylphenyl)-2-aminobutyric acid (7).The simultaneously formed dicarboxylic acid 9 was separated after N-arylsulphonylation.The reaction of the N-arylsulphonylated acids 10-15 with thionyl chloride afforded acid chlorides (16-18) with a cyano function from which carboxylic acid amides (19-39) were obtained by reaction with diffrent amines.These compounds were converted into the hydroiodides of the compounds named in the title via the thioamides and the thioimidic acid ester hydroiodides.