82100-82-1Relevant articles and documents
Synthesis and Mass Spectral Studies of Some 2-(3',5'-Dimethylpyrazol-1'-yl)-4-arylthiazoles and Their 4'-Alkyl/Carboxymethyl Analogues
Singh, S. P.,Kodali, Dharma R.,Dhindsa, G. S.,Sawhney, S. N.
, p. 30 - 33 (2007/10/02)
A number of 2-(3',5'-dimethylpyrazol-1'-yl)-4-arylthiazoles (IIa, d, g, j) and their 4'-alkyl (IIb, c, e, f, h, i, k, l) and 4'-carbethoxymethyl (III) analogues have been synthesized by the condensation of appropriate 2-hydrazino-4-arylthiazoles (I) with pentane-2,4-dione and its 3-substituted analogues.Alkaline hydrolysis of III gives the corresponding acids (IVa-d).The mass spectral studies reveal that the major fragmentation of II involves decomposition of pyrazole ring with the expulsion of methyl cyanide, fission of thiazole ring and the loss of methyl groupfrom the molecular ion.These and the other competing processes which involve skeletal rearrangement in the pyrazole moiety have been supported by the high resolution measurements.Presence of ethoxycarbonyl (III) or a carboxy function (IV), however, triggers an alternative low-energy pathway involving the preferential expulsion of these groups from the molecular ion prior to the decomposition of either of the heterocyclic moieties.The compounds have been screened for their antiinflammatory activity.
