82117-99-5

Upstream product

• 45534-08-5 5-amino-3-methylthio-1,2,4-triazole 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 73491-54-0 Nitroguanyl-imido-dithiokohlensaeuredimethylester 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 

Relevant academic research and scientific papers

Triazoles XXXVI . The Arylation of 5-Amino-3-methylthio-1H-1,2,4-triazole with Activated Aryl Chlorides

The possibility of the arylation of 5-amino-3-methylthio-1H-1,2,4-triazole (1) with different chlorobenzenes activated by a nitro group was studied.The ratio of products obtained was determined by hplc using isolated products as standards.It was stated that from among the monoarylated products 8, 9 and 10 obtained the main product is 8.However, from the reaction mixtures diarylated derivatives 11 and 12 and different by products such as 15, 16, 22, 24, 25, 27, 28, 32, 36, and 38 were also isolated.

Synthesis of Substituted 5-Amino-1,2,4-triazoles

N-Nitro-amidino-dithiocarbimidic acid dimethylester 1 reacts with monosubstituted hydrazines under formation of the substituted 5-amino-1,2,4-triazoles.Disubstituted hydrazines give under the same conditions N-nitro-amidino-S-methyl-isothiosemicarbazides.The reaction of some more hydrazine derivatives with 1 yields the adequate substituted 1,2,4-triazoles.