82119-82-2Relevant academic research and scientific papers
Novel synthetic approach for the access of functionalised 4H-chromenes
Sadeghpour, Mahdieh,Bagheri, Fatemeh
, p. 740 - 743 (2016/12/30)
A simple, efficient and high-yielding one-pot protocol for the synthesis of novel functionalised 4H-chromenes and chromene carboxylic acids has been developed using multi-component domino coupling reactions of anil-like compounds with 1,3-diketones and indole in the presence of formic acid catalyst under solvent-free conditions. The protocol avoids the use of expensive catalysts, toxic solvents and chromatographic separation.
Synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl)carbonyl]amino} -3,4-furandicarboxylates using a multi-component reaction in water
Adib, Mehdi,Sheikhi, Ehsan,Kavoosi, Azadeh,Bijanzadeh, Hamid Reza
experimental part, p. 9263 - 9269 (2011/01/12)
A simple synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl) carbonyl]amino}-3,4-furandicarboxylates via a one-pot multi-component reaction is described. The reactive 1:1 zwitterionic intermediate generated from the addition of isocyanides to dialkyl acetylenedicarboxylates was trapped at room temperature by coumarin-3-carboxylic acids prepared in situ from a 2-hydroxy aromatic aldehyde and Meldrum's acid to afford the title compounds in good to excellent yields.
