82127-17-1

Upstream product

• 82127-06-8 2-[1-(4-Bromo-phenyl)-3-oxo-3-thiophen-2-yl-propyl]-malononitrile 
• 103845-88-1 2-Bromo-2-[1-(4-bromo-phenyl)-3-oxo-3-thiophen-2-yl-propyl]-malononitrile 
• 68029-54-9 3-(4-bromophenyl)-2-cyanoprop-2-enethioamide 
• 66474-74-6 1-(1-Thiophen-2-yl-vinyl)-piperidine 

Downstream Products

• 82127-25-1 3-Amino-4-(4-bromo-phenyl)-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carbonitrile 
• 82127-21-7 4-(4-Bromo-phenyl)-2-cyanomethylsulfanyl-6-thiophen-2-yl-nicotinonitrile 

Relevant academic research and scientific papers

ACETYL-COA CARBOXYLASE MODULATORS

Provided herein are compounds that exhibit activity as acetyl-CoA carboxylase modulators (e.g., inhibitors) and are useful, for example, in methods for the control of fungal pathogens in plants.

CYCLIZATION OF NITRILES. XVII. METHODS FOR THE PRODUCTION OF 4,6-DIARYL-3-CYANO-2(1H)-PYRIDINETHIONES AND THEIR MASS-SPECTROMETRIC INVESTIGATION

The boundaries of the methods for the synthesis of 2(1H)-pyridinethiones were extended.The reactions of 3-aroyl-2-aryl- and 3-aroyl-2-aryl-1-bromo-1,1-dicyanopropanes with sodium and morpholinium hydrosulfides and thiourea and of arylidenecyanothioacetamides and 3-aryl-2,4,4-tricyano-3-butenethioamides with acetophenone, and 1-(1-piperidino)-1-phenylethylene, and also the reactions of monothiodibenzoylmethane and 1,3-diphenyl-1-(1-piperidino)-1-propene-3-one with cyanothioacetamide, leading to 4,6-diaryl-3-cyano-2(1H)-pyridinethiones, were investigated.The use of substituted cyanothioacetamides seems most promising.Mass-spectrometric investigation of the obtained thiones showed that the main direction in the dissociation of their molecular ions is the elimination of the H, HS., and CS particles with the formation of the thiazepinium and pyridinium ions and the corresponding radical-cation of pyrrole.