82140-88-3Relevant academic research and scientific papers
CHEMISTRY OF 2,2-DIMETHYL-1,3-DIOXOLE. TWO-CARBON HOMOLOGATION OF CARBONYL COMPOUNDS TO α-KETOALDEHYDES AND DIHYDROXYACETONYL MOIETIES
Flynn, Daniel L.,Mitscher, Lester A.,Veysoglu, Tarik,Wielogorski, Zbigniew
, p. 83 - 86 (2007/10/02)
The lithium salt of 2,2-dimethyl-1,3-dioxole adds readily to aldehydes and ketones to form the blocked dihydroxyacetonyl moiety.Only in favorable cases, however, can deblocking be accomplished without rearrangement.More commonly, acid-catalyzed deblocking leads to concommitant dehydration and results in excellent yields of α-ketoaldehydes rather than substituted dihydroxyacetones.
