82155-14-4

Upstream product

• 70908-62-2 (2-benzyloxycarbonylamino-ethyl)-phosphonic acid diethyl ester 
• 501-53-1 benzyl chloroformate 
• 82155-12-2 ethyl (2-aminoethyl)phosphonate 
• 64-17-5 ethanol 
• 88981-19-5 2-(N-benzyloxycarbonylamino)ethyl-phosphonic acid 

Downstream Products

• 1273492-39-9 (2-benzyloxycarbonylamino-ethyl)-methyl-phosphinic acid ethyl ester 
• 82168-78-3 Cbz-Aep(OEt)-Gly-OEt 

Relevant academic research and scientific papers

INHIBITORS OF FLAVIVIRIDAE VIRUSES

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Synthesis of Peptide Analogues Containing (2-Aminoethyl)phosphonic Acid (Ciliatine)

Di- and tripeptide analogues containing (2-aminoethyl)phosphonic acid , which has been discovered in a wide variety of living organisms, were prepared.As starting materials for incorporating the amino phosphonic acid into a peptide chain, the N-phthalylated diethyl ester and the N-carbobenzyloxylated monoalkyl ester were used.A phosphonamide bond between the amino phosphonic acid unit and amino acid unit was formed by reaction of Pht-Aep(OEt)Cl with amino acid ethyl ester or coupling reaction between Cbz-Aep(OR)(OH) and amino acid ethyl ester using diphenylphosphoryl azide-triethylamine as a condensing agent.Removal of the protecting groups was studied in connection with the acid-labile phosphonamide bond in the abnormal peptides.