82177-00-2Relevant academic research and scientific papers
ACTIVATION OF CONVENTIONAL S-PROTECTING GROUPS OF CYSTEINE BY CONVERSION INTO THE 3-NITRO-2-PYRIDINESULFENYL (NPYS) GROUP
Matsueda, Rei,Higashida, Susumu,Ridge, Richard J.,Matsueda, Gary R.
, p. 921 - 924 (2007/10/02)
All the conventional S-protecting groups of cysteine which were tested could be selectively converted to the 3-nitro-2-pyridine-sulfenyl (Npys) group after treatment with an appropriate Npys halide.Unidirectional formation of an unsymmetrical disulfide bond is possible when Cys(Npys) is mixed with a free thiol of another Cys residue.Some of these features were exploited during the solid phase synthesis of lysine8-vasopressin.
