821772-46-7

Upstream product

• 37942-07-7 3,5-di-tert-butyl-2-hydroxybenzaldehyde 
• 191480-63-4 (1R,2R)-1,2-diaminocyclohexane monohydrochloride 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 

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• 1163250-32-5 C₈₁H₁₁₀N₄O₈ 

Relevant academic research and scientific papers

Highly active polymer-supported (salen)Al catalysts for the enantioselective addition of cyanide to α,β-unsaturated imides

In this contribution, we describe polymer-supported (R,R)-(salen)AlCl complexes that were immobilized on poly(norbornene)s and display excellent activities and enantioselectivies as catalysts for the 1,4-conjugate addition of cyanide to α,β-unsaturated imides. These supported catalysts could be recycled up to 5 times without compromising catalyst activities or selectivities. Furthermore, the catalyst loadings could be reduced from 10-15 mol%, the common catalyst loadings for non-supported (salen) Al catalysts, to 5 mol%, a decrease of metal content by 50-66%, without lowering product yields or enantioselectivities. Kinetic studies indicated that the polymer-supported catalysts are significantly more active than their corresponding unsupported analogues, which makes this catalyst system key to a successful implementation of this catalytic transformation into the fine chemical and pharmaceutical industries.

Design and synthesis of binuclear Co-salen catalysts for the hydrolytic kinetic resolution of epoxides

Three binuclear Co(III)-salen complexes have been synthesized based on a series of hydrophilic cyclic frameworks with different ring sizes. The catalytic performance of Co-salen complexes have further been evaluated in the hydrolytic kinetic resolution of racemic epoxides. And kinetic studies reveal that the binuclear Co-salen catalysts show a higher reactivity and better enantioselectivity in comparison to monometallic reference complex, indicating the two Co-salen units on the cyclic framework may work in a cooperative manner. Specifically, Co3, with the most flexible cyclic framework exhibits the best catalytic performance among the three catalysts, due to the efficient cooperative interactions between two cobalt centers.

Asymmetric ring opening of epoxides with cyanides catalysed by chiral binuclear titanium complexes

A series of Schiff bases obtained from salicylaldehydes and 3,3′-diformyl-BINOL were synthesized. The complexes of these Schiff bases with Ti(IV) were active for the asymmetric ring opening of epoxides with TMSCN. A mixture of unpurified ligands was found

Chiral octahedral complexes of CoIII as a family of asymmetric catalysts operating under phase transfer conditions

Stereochemically inert and positively charged chiral complexes of Co III prepared from Schiff bases derived from chiral diamines and salicylaldehydes were shown to be efficient catalysts of the asymmetric phase transfer benchmark reaction of alkylation of O'Donnell's substrate with alkyl halides. The enantiomeric purities of the reaction products were up to 92%.

Olefin metathesis as a tool for multinuclear Co(III)salen catalyst construction: Access to cooperative catalysts

The construction of novel (macrocyclic) multinuclear Co(iii)salen catalysts is reported. Olefin metathesis has been used as a key construction tool for the multimetallic structures starting from versatile allyl-substituted salen scaffolds. The Co(iii) complexes were tested in the hydrolytic kinetic resolution of (rac)-1,2-epoxyhexane and epoxide ring opening reactions using methanol as the nucleophile. The preliminary results suggest a cooperative mode of catalysis in the case of bis-Co(iii)salen macrocycle 10. The Royal Society of Chemistry.

A versatile Co(bisalen) unit for homogeneous and heterogeneous cooperative catalysis in the hydrolytic kinetic resolution of epoxides

A study was conducted to demonstrate the synthesis of a versatile Co(bisalen) unit for homogeneous and heterogeneous cooperative catalysis in the hydrolytic kinetic resolution of expoxides. The styryl-substituted unsymmetrical bisalen was synthesized by f