821790-50-5Relevant academic research and scientific papers
Compound with cell proliferative resistance activity, preparation method and application
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Paragraph 0072; 0073; 0121; 0122; 0193; 0194; 0197; 0198, (2018/08/03)
The invention relates to a compound with cell proliferative resistance activity, a preparation method and application. The invention discloses a compound with cell proliferative resistance activity, as shown in formula I, pharmaceutically acceptable salt
4-Anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase
Spicer, Julie A.,Rewcastle, Gordon W.,Kaufman, Michael D.,Black, Shannon L.,Plummer, Mark S.,Denny, William A.,Quin III, John,Shahripour, Aurash B.,Barrett, Stephen D.,Whitehead, Christopher E.,Milbank, Jared B. J.,Ohren, Jeffrey F.,Gowan, Richard C.,Omer, Charles,Camp, Heidi S.,Esmaeil, Nadia,Moore, Kelley,Sebolt-Leopold, Judith S.,Pryzbranowski, Sally,Merriman, Ronald L.,Ortwine, Daniel F.,Warmus, Joseph S.,Flamme, Cathlin M.,Pavlovsky, Alexander G.,Tecle, Haile
, p. 5090 - 5102 (2008/03/13)
A new series of MEK1 inhibitors, the 4-anilino-5-carboxamido-2-pyridones, were designed and synthesized using a combination of medicinal chemistry, computational chemistry, and structural elucidation. The effect of variation in the carboxamide side chain,
5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS
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Page 92-93, (2010/02/10)
The present invention relates to 5-substituted-4-(substituted) phenylamino-2-pyridone derivatives of formula (I), pharmaceutical compositions and methods of use thereof as MEK inhibitors. Formula (I) wherein W is formula (II), formula (III), formula (IV),
