82180-50-5Relevant academic research and scientific papers
Probing for a hydrophobic a binding register in prostate-specific membrane antigen with phenylalkylphosphonamidates
Maung, Jack,Mallari, Jeremy P.,Girtsman, Teri A.,Wu, Lisa Y.,Rowley, Jennifer A.,Santiago, Nicholas M.,Brunelle, Alan N.,Berkman, Clifford E.
, p. 4969 - 4979 (2004)
A series of phenylalkylphosphonamidate derivatives of glutamic acid were synthesized and evaluated for their inhibitory potencies against PSMA. The greatest inhibitory potency was observed for the inhibitors 1f (n = 5) and 1g (n = 6) suggesting the presen
Mild and efficient Cs2CO3-promoted synthesis of phosphonates
Cohen, Richard J.,Fox, Daniel L.,Eubank, Jarrod F.,Salvatore, Ralph Nicholas
, p. 8617 - 8621 (2007/10/03)
A mild and convenient synthesis for phosphonates using cesium carbonate (Cs2CO3), tetrabutylammonium iodide (TBAI) and DMF was developed at room temperature. Numerous dialkyl phosphites were screened using a diverse array of alkyl halides and these reaction conditions were found to be highly efficient producing various phosphonates exclusively in moderate to high yields.
