822-48-0

Basic information

• Product Name: 2-(CHLOROMETHYL)-2-METHYL-1,3-EPOXYPROPANE
• Synonyms: 3-(chloromethyl)-3-methyl-oxetan;2-(CHLOROMETHYL)-2-METHYL-1,3-EPOXYPROPANE;3-(CHLOROMETHYL)-3-METHYLOXETANE;3-methyl-3-chloromethyloxetane;2-(chloromethyl)-1,3-epoxy-2-methylpropane
• CAS NO: 822-48-0
• Molecular Formula: C₅H₉ClO
• Molecular Weight: 120.58
• Product Categories: Oxetanes;Simple 4-Membered Ring Compounds
• Mol File: 822-48-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 88 °C / 97.5mmHg
• Flash Point: 42.9 °C
• Appearance: /
• Density: 1.10
• Vapor Pressure: 7.82mmHg at 25°C
• Refractive Index: 1.4480-1.4520
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(CHLOROMETHYL)-2-METHYL-1,3-EPOXYPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-2-METHYL-1,3-EPOXYPROPANE(822-48-0)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-2-METHYL-1,3-EPOXYPROPANE(822-48-0)

Safety Data

• RIDADR: 1993
• RTECS: RQ6828000
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 822-48-0(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-2-methyl-1,3-epoxypropane is a chemical compound that features in the creation of multiple chemical products. It is an organic compound and is also known as glycidyl methyl chloromethyl ether. Like many similar compounds, it is a liquid which can cause serious harm if inhaled, swallowed, or in contact with the skin. Due to its hazardous nature, this chemical is generally used under strict industrial safety measures. It is most commonly applied in the fields of the chemical and pharmaceutical industries, particularly in the synthesis of chemical and pharmaceutical intermediates, due to its reactivity. Commercially, it often requires special handling and storage conditions to ensure safety and maintain its chemical properties.

InChI:InChI=1/C5H9ClO/c1-5(2-6)3-7-4-5/h2-4H2,1H3

Upstream product

• 3143-02-0 3-hydroxymethyl-3-methyloxethane 
• 78-71-7 3,3-bis(chloromethyl)oxetane 
• 77-85-0 2-(hydroxymethyl)-2-methylpropane-1,3-diol 
• 13431-60-2 2,2-Bis(chloromethyl)propyl acetate 

Downstream Products

• 4777-10-0 4-(3-methyl-oxetan-3-ylmethyl)-morpholine 
• 90683-29-7 3-(azidomethyl)-3-methyloxetane 
• 1228450-51-8 C₆H₁₂N₂OS 
• 1263396-69-5 6-(2-aminopyrimidin-5-yl)-2-((3-methyloxetan-3-yl)methyl)-8-(oxetan-3-ylamino)-2,7-naphthyridin-1(2H)-one 

Relevant articles and documents

Tripod Ligands with Three Different Donor Groups: Synthesis and Coordination of CH3C(CH2PR2)(CH2PR'2)(CH2PR"2)

Tripod ligands CH3C(CH2PR2)(CH2PR'2)(CH2PR"2), 6(a-e), with three different donor groups are obtained from CH3C(CH2Cl)(CH2Br)(CH2OSO2CF3), 3, by successive replacement of the three different leaving groups. 3 itself is easily accessible from CH3C(CH2OH)3 in a few simple steps.The general applicability of this strategy is demonstrated by the preparation of five different ligands 6(a-e).For one specific example (6a) the coordination behavior is exemplified by the synthesis of its Mo(CO)3 derivative: CH3C(CH2P(Ph)2)(CH2P(3-Tol)2)(CH2P(4-Tol)2)*Mo(CO)3 (7).All compounds, including their intermediates CH3C(CH2Cl)(CH2Br)(CH2PR2), 4(a-c), and CH3C(CH2PR2)(CH2PR'2)(CH2Cl), 5(a-c), have been obtained in an analytically pure state and fully characterized by their spectroscopic data.The methods developed lend themselves to the almost deliberate shaping of tripod metal templates.Key words: Chiral Tripod Ligands, Chiral Tripod-Molybdenum Complexes, Synthesis, Chiral Triphosphines, Functionalized Neopentyl Compounds

SYNTHESIS AND BRONCHOLYTIC ACTIVITY OF 3,3-DISUBSTITUTED OXETANES

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