82202-32-2

Basic information

• Product Name: 2-AMino-5-broMo-4-t-butylthiazole
• Synonyms: 2-AMino-5-broMo-4-t-butylthiazole;5-Bromo-4-(tert-butyl)thiazol-2-amine
• CAS NO: 82202-32-2
• Molecular Formula: C7H11BrN2S
• Molecular Weight: 235.14464
• Mol File: 82202-32-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-AMino-5-broMo-4-t-butylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-5-broMo-4-t-butylthiazole(82202-32-2)
• EPA Substance Registry System: 2-AMino-5-broMo-4-t-butylthiazole(82202-32-2)

Safety Data

• Hazardous Substances Data: 82202-32-2(Hazardous Substances Data)

Usage

Description

2-Amino-5-bromo-4-t-butylthiazole is a chemical compound with the molecular formula C8H10BrN2S. It is a brominated thiazole derivative with a t-butyl group. 2-AMino-5-broMo-4-t-butylthiazole is characterized by its unique chemical structure and properties, making it a valuable building block in various applications.

Uses

Used in Organic Synthesis:
2-Amino-5-bromo-4-t-butylthiazole is used as a building block in organic synthesis for the creation of various pharmaceuticals and bioactive compounds. Its unique chemical structure allows for the development of new and innovative molecules with potential therapeutic and industrial applications.
Used in Pharmaceutical Research:
In pharmaceutical research, 2-Amino-5-bromo-4-t-butylthiazole is utilized as a key component in the design and synthesis of new drugs. Its interesting chemical properties make it a promising candidate for the development of novel therapeutic agents.
Used in Agrochemical Development:
2-Amino-5-bromo-4-t-butylthiazole may also have potential applications in the development of new agrochemicals. Its unique chemical properties could contribute to the creation of innovative products for agricultural use.
Safety Precautions:
It is important to handle 2-Amino-5-bromo-4-t-butylthiazole with care, as it may pose health and environmental risks if not used properly. Proper safety measures should be taken to minimize any potential hazards associated with this chemical compound.
Overall, 2-Amino-5-bromo-4-t-butylthiazole is a valuable chemical for the advancement of scientific research and the development of new products in various industries, including pharmaceuticals and agrochemicals.

Upstream product

• 5469-26-1 1-Bromopinacolon 
• 128-08-5 N-Bromosuccinimide 
• 74370-93-7 2-amino-4-tert-butylthiazole 

Downstream Products

• 439146-07-3 2-acetoxy-5-bromo-N-{4-[(1,1-dimethyl)ethyl]-5-piperidinothiazol-2-yl}benzamide 

Relevant articles and documents

NF-KB ACTIVATION INHIBITORS

A medicament having inhibitory activity against NF-κB activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1○ a fused polycyclic heteroaryl group wherein the ring which binds directly to ―CONH― group in the formula (I) is a benzene ring, 2○ unsubstituted thiazol-2-yl group, or 3○ unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ― CONH―E wherein E has the same meaning as that defined above.

REMEDIES FOR NEURODEGENERATIVE DISEASES

A medicament for preventive and/or therapeutic treatment of neurodegenerative diseases such as Alzheimer's disease or the like which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1○ a fused polycyclic heteroaryl group wherein the ring which binds directly to -CONH- group in the formula (I) is a benzene ring, 2○ unsubstituted thiazol-2-yl group, or 3○ unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above.

IMMUNITY-RELATED PROTEIN KINASE INHIBITORS

[From equivalent EP1510210A1] A medicament having an inhibitory activity against IKK-Aβ and/or MEKK-1 or other protein kinases structurally similar thereto, which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -X-E wherein each of X and E has the same meaning as that defined above.