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Usage

Uses

Used in Pharmaceutical Industry:
Andrographoside is used as a therapeutic agent for its anti-inflammatory properties, making it a potential treatment for various inflammatory conditions. Its immunomodulatory effects also contribute to its potential use in managing immune system-related disorders.
Used in Nutraceutical Industry:
Andrographoside is used as a dietary supplement for its health-promoting benefits, such as enhancing the immune system and providing support for overall well-being. Its natural origin and wide range of effects make it an attractive option for consumers seeking natural alternatives to synthetic medications.
Used in Cosmetic Industry:
Andrographoside is used as an active ingredient in skincare products for its anti-inflammatory and cell signaling properties. It may help reduce inflammation, promote skin healing, and improve overall skin health, making it a valuable addition to cosmetic formulations.
Used in Research Applications:
Andrographoside is used as a research tool for studying the mechanisms of action behind its various biological activities. Its role in modulating cell signaling pathways and immune responses can provide valuable insights into the development of new therapeutic strategies and drug candidates.

InChI:InChI=1/C26H40O10/c1-13-4-7-18-25(2,15(13)6-5-14-16(28)11-34-23(14)33)9-8-19(29)26(18,3)12-35-24-22(32)21(31)20(30)17(10-27)36-24/h5,15-22,24,27-32H,1,4,6-12H2,2-3H3/b14-5+/t15?,16-,17-,18+,19-,20-,21+,22-,24-,25+,26+/m1/s1

Upstream product

• 142037-79-4 andrographolide 
• 2816-24-2 o-nitrophenyl D-galactopyranoside 
• 133-89-1 UDP-glucose 

Relevant academic research and scientific papers

Efficient enzymatic synthesis and antibacterial activity of andrographolide glycoside

19-O-β-Galactosyl andrographolide, a potential novel antibacterial agent, was synthesized through enzymatic transgalactosylation of andrographolide in co-solvent systems. Organic solvents and their contents have important influences on the regioselective galactosylation of andrographolide catalyzed by β-galactosidase from bovine liver in co-solvent systems. β-Galactosidase showed high activity and stability in 5-15% (v/v) DMSO with 22-52% total molar yields of andrographolide glycosides. The addition of hydrophilic DMSO not only greatly promoted the solubility of the substrate, but also improved the reaction efficiency of the process. β-Galactosidase displayed absolute regioselectivity toward the 19-position of andrographolide. The solubility of andrographolide glycoside in water was 42.1 mg ml-1, which is about 702 times that of andrographolide. The glycosylated andrographolide showed antibacterial activity against five representative species of food-borne pathogenic bacteria [with minimal inhibitory concentrations (MICs) as low as 8 μg ml-1], whereas andrographolide exhibited no such activity. These results indicate an enzymatic modification was not only facile and green, but an effective method for the preparation of an andrographolide monoglycoside.

Glucosyltransferase Capable of Catalyzing the Last Step in Neoandrographolide Biosynthesis

ApUGT, a diterpene glycosyltransferase from Andrographis paniculata, could transfer a glucose to the C-19 hydroxyl moiety of andrograpanin to form neoandrographolide. This glycosyltransferase has a broad substrate scope, and it can glycosylate 26 natural and unnatural compounds of different structural types. This study provides a basis for exploring the glycosylation mechanism of ent-labdane-type diterpenes and plays an important role in diversifying the structures used in drug discovery.