82212-02-0

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-METHYLPHENYL) PIPERIDINE HYDROCHLORIDE is used as a pharmaceutical intermediate for the synthesis of various drugs, particularly those targeting mood disorders such as depression and anxiety. Its role as a reuptake inhibitor of serotonin and norepinephrine makes it instrumental in the treatment of these conditions by modulating neurotransmitter levels in the brain.
Used in Neurological and Psychiatric Medication Development:
In the field of neurological and psychiatric medication, 4-(2-METHYLPHENYL) PIPERIDINE HYDROCHLORIDE is utilized as a key component in the creation of medications aimed at treating a range of conditions. Its ability to inhibit the reuptake of certain neurotransmitters contributes to its therapeutic potential in managing the symptoms of various mental health disorders.

Upstream product

• 630116-52-8 4-(2'-methylphenyl)piperidine 
• 95-46-5 2-methylphenyl bromide 
• 932-31-0 ortho-tolylmagnesium bromide 
• 821768-11-0 1,2,3,6-tetrahydro-4-(2-methylphenyl)-1-(phenylmethyl)-pyridine 
• 1370256-34-0 1-benzyl-4-(2-methylphenyl)-1,2,3,6-tetrahydropyridinium chloride 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 83674-75-3 1-benzyl-4-o-tolylpiperidin-4-ol 

Relevant academic research and scientific papers

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.

CYCLOALKANOPYRIDINE DERIVATIVE

Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.