82212-04-2

Basic information

• Product Name: 4-(2-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE
• Synonyms: 4-(2-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE;4-(2-Methoxyphenyl)piperidine HCl
• CAS NO: 82212-04-2
• Molecular Formula: C12H18ClNO
• Molecular Weight: 227.73
• Mol File: 82212-04-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE(82212-04-2)
• EPA Substance Registry System: 4-(2-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE(82212-04-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 82212-04-2(Hazardous Substances Data)

Usage

General Description

4-(2-Methoxyphenyl) piperidine hydrochloride is a chemical compound with the molecular formula C14H20ClNO. It is a piperidine derivative and acts as a selective dopamine D2 receptor antagonist. 4-(2-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE is used in pharmacological research as a tool compound to study the function of dopamine receptors and their role in various physiological and pathological processes. Additionally, it has potential applications in the development of novel medications for conditions such as schizophrenia, bipolar disorder, and Parkinson's disease. The hydrochloride salt form of the compound enhances its stability and solubility, making it more suitable for experimental and therapeutic use.

Upstream product

• 5958-00-9 4-(2-methoxylphenyl)pyridine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 578-57-4 2-bromoanisole 
• 201609-29-2 1-t-Butoxycarbonyl-4-(2-methoxyphenyl)piperidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 497-19-8 sodium carbonate 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1004760-10-4 4-(2-methoxyphenyl)pyridine hydrochloride 
• 1120-87-2 4-bromopyridin 

Relevant articles and documents

Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators

Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors have been implicated in a wide variety of CNS disorders, but despite extensive efforts to develop small molecule ligands there are few reports of such compounds. Herein we describe the optimization of a quinazoline based lead to give 18 (SBI-553), a potent and brain penetrant NTR1 allosteric modulator.

1-[(1-methyl-1 H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis

A novel series of mGluR2 positive allosteric modulators (PAMs), 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines, is herein disclosed. Structure-activity relationship studies led to potent, selective mGluR2 PAMs with excellent pharmacokinetic profiles. A representative lead compound (+)-17e demonstrated dose-dependent inhibition of methamphetamine-induced hyperactivity and mescaline-induced scratching in mice, providing support for potential efficacy in treating psychosis.

BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.