82215-18-7Relevant academic research and scientific papers
An improved synthesis of β-cyano- l -alanine esters and amides
Wang, Guoxin,Chen, Longjian,Cai, Xiaodan,Li, Zigang,Luo, Ming
supporting information, p. 309 - 312 (2016/01/20)
We have developed a novel, mild, efficient, and scalable protocol for the synthesis of N-protected β-cyano-l-alanine esters or -amides from N-protected l-asparagin. This protocol avoided the use of toxic or unpleasant reagents and was easy to operate in laboratory.
A concise synthesis of β-asparaginyladenylate
Ding, Yun,Wang, Jianqiang,Schuster, Sheldon M.,Richards, Nigel G. J.
, p. 4372 - 4375 (2007/10/03)
Stable analogues of acyladenylate intermediates, such as N-acylphosphoramidates, are useful probes of tRNA aminoacylation and enzyme mechanism, and have potential application as enzyme inhibitors. We now report a concise, "one-pot" synthesis of β-asparaginyladenylate using a novel coupling protocol that yields the target N-acylphosphor-amidate in three reactions from readily available precursors. This simple synthetic procedure may represent a general approach for the preparation of functionalized N-acylphosphoramidates from amides that do not undergo coupling under the conditions of existing literature protocols.
AMINO ACID SURROGATES : AN INDIRECT METHOD FOR THE SYNTHESIS OF PEPTIDES CONTAINING THE THIOASPARAGINYL RESIDUE
Saneii, Hossain,Spatola, Arno F.
, p. 149 - 152 (2007/10/02)
The protected pentapeptide, Boc-Tan-Cys(PMB)-Pro-Leu-GlyNH2 and related thioasparaginyl compounds were prepared by an indirect method from their corresponding β-cyanoalanyl precursors by treatment with H2S/NH3.The optical purities of thioasparagine (Tan)
