82217-01-4

Basic information

• Product Name: m-PEG9-Tos
• Synonyms: m-PEG9-Tos
• CAS NO: 82217-01-4
• Molecular Formula: C₂₄H₄₂O₁₁S
• Molecular Weight: 538.64868
• Mol File: 82217-01-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: m-PEG9-Tos(CAS DataBase Reference)
• NIST Chemistry Reference: m-PEG9-Tos(82217-01-4)
• EPA Substance Registry System: m-PEG9-Tos(82217-01-4)

Safety Data

• Hazardous Substances Data: 82217-01-4(Hazardous Substances Data)

Usage

Description

m-PEG9-Tos is a PEG linker containing a tosyl group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Upstream product

• 25990-96-9 octaethylene glycol monomethyl ether 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 869718-83-2 C₂₅H₄₃BrO₉ 
• 1384529-69-4 1-(octaethyleneglycol)-4-phenylpyridinium chloride 
• 869718-84-3 C₂₆H₄₄O₁₁ 
• 869718-81-0 2,5,8,11,14,17,20,23-octaoxapentacosan-25-amine 
• 1056881-04-9 octaethylene glycol monomethyl ether bromide 
• 1395493-58-9 (S)-27-methyl-28-benzyloxy-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane 
• 1395493-67-0 (R)-27-methyl-28-benzyloxy-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane 

Relevant articles and documents

Synthesis and photophysical characterization of highly water-soluble PEGylated BODIPY derivatives for cellular imaging

A series of poly(ethylene glycol) (PEG)-modified water-soluble boron dipyrromethene (BODIPY) dyes (EtBOD-PEG and BOD-PEG) were synthesized and their photophysical properties in various solutions were investigated. The presence of ethyl groups at the 2,6-p

A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS

Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.

Visible-Light-Induced Cysteine-Specific Bioconjugation: Biocompatible Thiol–Ene Click Chemistry

Bioconjugation methods using visible-light photocatalysis have emerged as powerful synthetic tools for the selective modification of biomolecules under mild reaction conditions. However, the number of photochemical transformations that allow successful protein bioconjugation is still limited because of the need for stringent reaction conditions. Herein, we report that a newly developed water-compatible fluorescent photosensitizer QPEG can be used for visible-light-induced cysteine-specific bioconjugation for the installation of QPEG by exploiting its intrinsic photosensitizing ability to activate the S?H bond of cysteine. The slightly modified QCAT enables the effective photocatalytic cysteine-specific conjugation of biologically relevant groups. The superior reactivity and cysteine selectivity of this methodology was further corroborated by traceless bioconjugation with a series of complex peptides and proteins under biocompatible conditions.