82222-48-8

Upstream product

• 134835-13-5 1-<(4'-nitrophenylimino)methyl>-2-naphthol 
• 41381-89-9 2-(4-phenylthiazol-2-yl)acetonitrile 
• 69015-72-1 3-oxo-3H-benzo[f]chromene-2-carbothioic acid amide 
• 70-11-1 α-bromoacetophenone 
• 135-19-3 β-naphthol 

Relevant academic research and scientific papers

Ensembles of rings with a coumarin unit. 1. Synthesis of 3-(2-R-thiazol-4-yl)- and 3-(4-R-triazol-2-yl)coumarins

We have synthesized 3-(2-R-thiazol-4-yl)coumarins (R = H, CH3, CH2CN, Ar) by condensation of 3-(α-bromoacetyl)coumarins with thioamides. We obtained 3-(4-R-thiazol-2-yl)coumarins (R = H, Ar) by several methods. By reaction of 2-cyanomethyl-4-phenylthiazole with 2-hydroxybenzaldehydes, we synthesized 2-imino-3-(4-phenylthiazol-2-yl)coumarins, which were converted to the corresponding coumarins by acid hydrolysis. For 3-(2-R-thiazol-4-yl)coumarins (R = CH2CN), we carried out reactions with aromatic aldehydes. We propose alternative methods for synthesis of 2-[2-aryl(hetaryl)-1-cyanoethenyl]-4-(coumarin-3-yl)thiazoles. 1998 Plenum Publishing Corporation.

A Simple Route to N(2'-Hydroxy)-arylidene-nitroanilines-Versatile Synthones for Coumarines

In a three-component reaction with ortho formic esters and nitroaniline activated phenols are easily transferred to N(2'-hydroxy)-arylidene-nitroanilines.The reaction is commonly applicable and gives the N(2'-hydroxy-4'-N,N-dialkylamino)-benzylidene-nitroanilines 10 in good yields also with the air-unstable m-N,N-dialkylaminophenols 8.The prepared 2-hydroxy-azomethines are convertable into boroncomplexes 14 and coumarine derivatives 17, respectively.