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UCB-JO28, also known as 4-(4-fluorophenyl)-N-[(1S)-1-(6-fluoro-1,2-benzisoxol-3-yl)ethyl]-N-(2-hydroxyethyl)-1,3-thiazol-2-amine, is a potent and selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). This enzyme plays a crucial role in the regulation of glucose homeostasis by degrading incretin hormones, which are responsible for stimulating insulin secretion and suppressing glucagon release. By inhibiting DPP-4, UCB-JO28 helps to prolong the action of these hormones, thereby improving blood glucose control in patients with type 2 diabetes. The chemical is characterized by its unique structure, which includes a 1,3-thiazol-2-amine core, a benzisoxol-3-yl moiety, and a 4-fluorophenyl group, all of which contribute to its high affinity and selectivity for the DPP-4 enzyme.

82227-38-1

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82227-38-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 82227-38-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,2,2 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 82227-38:
(7*8)+(6*2)+(5*2)+(4*2)+(3*7)+(2*3)+(1*8)=121
121 % 10 = 1
So 82227-38-1 is a valid CAS Registry Number.
InChI:InChI=1/C24H29NO4.ClH/c26-23(27)19-29-18-17-28-16-15-25-13-11-22(12-14-25)24(20-7-3-1-4-8-20)21-9-5-2-6-10-21;/h1-10H,11-19H2,(H,26,27);1H

82227-38-1Upstream product

82227-38-1Downstream Products

82227-38-1Relevant academic research and scientific papers

2-[4-(Diphenylmethylene)-1-piperidinyl]-acetic acids and their amides

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, (2008/06/13)

New 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids and their amides, processes for the preparation thereof and therapeutic compositions. These compounds have the formula STR1 wherein Y=--OH or --NR1 R2, R1 and R2 =H, alkyl or phenyl; X=H, halogen or alkoxy; m=0, 1 or 2 and n=1 or 2. The 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester, whereas the amides are prepared either by reacting a 4-(diphenylmethylene)-piperidine with an omega-haloacetamide, or by reacting an alkali metal salt of an omega-[4-diphenylmethylene)-1-piperidinyl]-alkanol (m=1 or 2) with a 2-haloacetamide, or by reacting a nitrogen compound (HNR1 R2) with a halide or alkyl ester of a 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acid. These compounds have in particular an antiallergic, spasmolytic, antihistaminic and broncholytic activity.

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