82275-95-4Relevant academic research and scientific papers
RING-CLOSURE REACTIONS. XXIV. KINETICS OF FORMATION OF MEDIUM - AND LARGE-RING N-TOSYLAZACYCLOALKANES. ROLE OF RING STRAIN ON MEDIUM-RING FORMATION
Galli, Carlo,Gargano, Patrizia,Mandolini, Luigi
, p. 653 - 658 (2007/10/02)
The kinetics of closure of N-tosylazacycloalkanes from the anions derived from N-tosyl-ω-bromoalkylamines have been investigated in 99percent aqueous Me2SO.Rate constants and effective molarities (EM) have now been obtained for the ring sizes 8-13, 17, an
RING-CLOSURE REACTIONS. XX. AN EFFICIENT SYNTHESIS OF MANY-MEMBERED AZACYCLOALKANES
Gargano, Patrizia,Mandolini, Luigi
, p. 31 - 34 (2007/10/02)
An efficient cyclization of N-tosyl-ω-bromoalkylamines to N-tosylazacycloalkanes in the presence of a combination of EtOK/K2CO3 in Me2SO solution is described.This base-solvent system permitted the high-dilution conditions favourable to cyclization to be attained with a conveniently high rate of feed of the bifunctional reactants into the reaction medium.Yields are very good for the large rings, and still satisfactory, although significantly lower, for the medium-sized rings.
