82292-44-2Relevant academic research and scientific papers
Interpenetrated metal-organic frameworks of self-catenated four-connected mok nets
Gong, Yun,Zhou, Yu-Chao,Liu, Tian-Fu,Lue, Jian,Proserpio, Davide M.,Cao, Rong
, p. 5982 - 5984 (2011)
We describe two cobalt metal-organic frameworks built by amide derivative and organodicarboxyl co-ligands, displaying 3-fold interpenetration of 6 5.8-mok nets which are 4-connected self-catenated nets described theoretically in the early nineties.
Increased Photocatalytic Activity of Post Synthetically Modified Coordination Polymer Derived from Bis-pyridyldiamide
Das, Moyna,Khullar, Sadhika,Sarkar, Madhushree
, (2020)
A one-dimensional looped chain coordination polymer (CP1) is synthesized by the reaction of CoII with N1,N3-di(pyridine-4-yl)isophthalamide. Transmetalation reaction of CP1 with CuII showed single-crystal-to-sin
Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum
Wicht, Kathryn J.,Combrinck, Jill M.,Smith, Peter J.,Hunter, Roger,Egan, Timothy J.
, p. 6512 - 6530 (2016/07/23)
Quinoline antimalarials target hemozoin formation causing a cytotoxic accumulation of ferriprotoporphyrin IX (Fe(III)PPIX). Well-developed SAR models exist for β-hematin inhibition, parasite activity, and cellular mechanisms for this compound class, but no comparably detailed investigations exist for other hemozoin inhibiting chemotypes. Here, benzamide analogues based on previous HTS hits have been purchased or synthesized. Only derivatives containing an electron deficient aromatic ring and capable of adopting flat conformations, optimal for π-π interactions with Fe(III)PPIX, inhibited β-hematin formation. The two most potent analogues showed nanomolar parasite activity, with little CQ cross-resistance, low cytotoxicity, and high in vitro microsomal stability. Selected analogues inhibited hemozoin formation in Plasmodium falciparum causing high levels of free heme. In contrast to quinolines, introduction of amine side chains did not lead to benzamide accumulation in the parasite. These data reveal complex relationships between heme binding, free heme levels, cellular accumulation, and in vitro activity of potential novel antimalarials.
Thioamide, urea and thiourea bridged rhenium(I) complexes as luminescent anion receptors
Odago, Maurice O.,Hoffman, Amanda E.,Carpenter, Russell L.,Tse, Douglas Chi Tak,Sun, Shih-Sheng,Lees, Alistair J.
experimental part, p. 558 - 565 (2011/09/16)
Thioamides, urea and thiourea derivatives of 2,6-pyridinedicarbonyl dichloride, isophthaloyl dichloride and terephthaloyl dichloride have been synthesized. These ligands have been incorporated in dinuclear rhenium(I) diimine tricarbonyl complexes and the
