82296-99-9Relevant academic research and scientific papers
170. Asymmetric Palladium-Assisted Alkylation of Alkenes
Solladie-Cavallo, Arlette,Haesslein, Jean-Luc
, p. 1760 - 1773 (2007/10/02)
Palladium-promoted alkylation of alkenes using chiral sulfoxide-containing carbanions and chiral lithiated oxazolines results in asymmetric induction (AI) ranging from 3-5 percent (1,5 induction), 20-40 percent (1,3 induction) to 44-52 percent (1,4 induction).No general trend allowing predictions of results was found.With 1-hexene, attack at C(1) is almost exclusive but propene gives a mixture of attack at C(1) and C(2).The use of a chiral ligand together with malonate anion also leads to some asymmetric induction (ca. 20 percent).
ASYMMETRIC PALLADIUM-ASSISTED ALKYLATION OF OLEFINS
Solladie-Cavallo, A.,Haesslein, J. L.,Baeckvall, Jan-E.
, p. 939 - 942 (2007/10/02)
Palladium-promoted alkylation of some alkenes using chiral sulfoxide-containing carbanion as nucleophiles or using optically active N,N-dimethyl-α-phenylethylamine as ligand together with a non-chiral stabilized carbanion as nucleophile results in an asymmetric induction of 10-40percent.
