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Usage

Uses

Used in Organic Synthesis:
3,5-Dichlorophenylmagnesium bromide is used as a key synthetic intermediate for the preparation of non-alternant polycyclic hydrocarbons, such as indeno-benzophenalene. Its reactivity allows for the formation of complex molecular structures that are otherwise difficult to synthesize.
Used in the Synthesis of Carboxylic Esters:
In this application, 3,5-dichlorophenylmagnesium bromide serves as a substrate in the synthesis of carboxylic esters. It reacts with 2-methyl-4,6-pyrimidyl dicarbonates, leading to the formation of esters that can be used in various chemical and pharmaceutical processes.
Used in the Synthesis of Aryl Ketones:
3,5-Dichlorophenylmagnesium bromide is also utilized as a substrate in the synthesis of aryl ketones. It reacts with acid chlorides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether ligand, facilitating the formation of aryl ketones that are important building blocks in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

InChI:InChI=1/C6H3Cl2.BrH.Mg/c7-5-2-1-3-6(8)4-5;;/h2-4H;1H;/q;;+1/p-1/rC6H3BrCl2Mg/c7-10-6-2-4(8)1-5(9)3-6/h1-3H

Upstream product

• 19752-55-7 1-bromo-3,5-dichlorobenzene 

Downstream Products

• 103021-75-6 9-(3,5-dichlorophenyl)fluoren-9-ol 
• 131180-61-5 (S)-α,α-Bis(3,5-dichlorophenyl)-2-pyrrolidinemethanol 
• 191722-41-5 1,3-Dichloro-5-vinylsulfanyl-benzene 
• 201412-94-4 (Z)-2-Bromo-3-(3,5-dichloro-phenyl)-acrylic acid methyl ester 
• 317832-88-5 bis(3,5-dichlorophenyl)phosphine oxide 
• 943437-03-4 1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one 
• 223128-60-7 1,3-dichloro-5-(1-chloro-1,3,3-trimethyl-butyl)-benzene 
• 51053-82-8 (3,5-Cl₂C₆H₃)3SnC₆H₄-p-F 
• 1142905-80-3 1-(4-amino-3,5-dibromo-phenyl)-1-(3,5-dichloro-phenyl)-2,2,2-trifluoro-ethanol 
• 144895-73-8 4-methoxyphenyl 3,5-dichlorobenzoate 

Relevant academic research and scientific papers

Synthesis of trifluoromethylated α-hydroxy acids and their derivatives based on alkyl trifluoropyruvates

The reactions of trifluoropyruvates with nitromethane and arylmagnesium bromides leading to trifluoromethyl-containing α-hydroxy acid esters were studied and various derivatives of the acids were obtained.

Process for producing 3,5-dichloro-α-methylstyrene

1-Bromo-3,5-dichlorobenzene is reacted with magnesium in a solvent and acetone is added to react it with the reaction product and a mineral acid is added to hydrolyze the resulting α-(3,5-dichlorophenyl) isopropoxymagnesium bromide and then, the product i