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• 35371-03-0 4-iodothioanisole 
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Relevant academic research and scientific papers

Electrocatalytic Deuteration of Halides with D2O as the Deuterium Source over a Copper Nanowire Arrays Cathode

Precise deuterium incorporation with controllable deuterated sites is extremely desirable. Here, a facile and efficient electrocatalytic deuterodehalogenation of halides using D2O as the deuteration reagent and copper nanowire arrays (Cu NWAs) electrochemically formed in situ as the cathode was demonstrated. A cross-coupling of carbon and deuterium free radicals might be involved for this ipso-selective deuteration. This method exhibited excellent chemoselectivity and high compatibility with the easily reducible functional groups (C=C, C≡C, C=O, C=N, C≡N). The C?H to C?D transformations were achieved with high yields and deuterium ratios through a one-pot halogenation–deuterodehalogenation process. Efficient deuteration of less-active bromide substrates, specific deuterium incorporation into top-selling pharmaceuticals, and oxidant-free paired anodic synthesis of high-value chemicals with low energy input highlighted the potential practicality.

Reductive deamination of aromatic amines with nitric oxide (NO)

Aromatic amines were treated with nitric oxide in tetrahydrofuran or chloroform under argon atmosphere to afford deaminated aromatic compounds in good yields. The reaction is suggested to proceed via aryl radicals, which are supposed to be formed by reduction of aryldiazonium salts with NO.

Ion-neutral complex formation and hydrogen-shifts in the alkene loss from ionized alkyl phenyl thioethers in the gas phase

The mechanistic aspects of alkene loss from ionized ethyl- and n-propyl phenyl thioethers have been studied by use of deuterium labelling and tandem mass spectrometry. Loss of ethene from the molecule ion of ethyl phenyl thioether proceeds predominantly b