823189-01-1

Basic information

• Product Name: Benzene, 1-(2-azidoethyl)-4-fluoro-
• CAS NO: 823189-01-1
• Molecular Formula: C8H8FN3
• Molecular Weight: 165.17
• Mol File: 823189-01-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2-azidoethyl)-4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2-azidoethyl)-4-fluoro-(823189-01-1)
• EPA Substance Registry System: Benzene, 1-(2-azidoethyl)-4-fluoro-(823189-01-1)

Safety Data

• Hazardous Substances Data: 823189-01-1(Hazardous Substances Data)

Upstream product

• 332-43-4 1-(2-chloroethyl)-4-fluorobenzene 
• 40759-47-5 1-(2-methanesulfonyloxyethyl)-4-fluorobenzene 
• 332-42-3 (2-bromoethyl)-4-fluorobenzene 

Downstream Products

• 1044255-48-2 C₂₃H₂₃FN₄O₃S 
• 1602733-04-9 C₂₃H₂₀FN₅O 
• 1316652-07-9 C₁₇H₁₅FN₄O₂ 
• 1034981-24-2 N-benzyl-2-(1-(4-fluorophenethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxamide 

Relevant articles and documents

Synthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization

Herein, we report a metal-free synthesis of cyclic amidines, oxazines, and an oxazinone under mild conditions by electrophilic amide activation. This strategy features an unusual Umpolung cyclization mode and enables the smooth union of α-aryl amides and diverse alkylazides, effectively rerouting our previously reported α-amination transform.

Nickel-Catalyzed Azide-Alkyne Cycloaddition to Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water

Transition-metal-catalyzed or metal-free azide-alkyne cycloadditions are methods to access 1,4- or 1,5-disubstituted 1,2,3-triazoles. Although the copper-catalyzed cycloaddition to access 1,4-disubstituted products has been applied to biomolecular reaction systems, the azide-alkyne cycloaddition to access the complementary 1,5-regioisomers under aqueous and ambient conditions remains a challenge due to limited substrate scope or moisture-/air-sensitive catalysts. Herein, we report a method to access 1,5-disubstituted 1,2,3-triazoles using a Cp2Ni/Xantphos catalytic system. The reaction proceeds both in water and organic solvents at room temperature. This protocol is simple and scalable with a broad substrate scope including both aliphatic and aromatic substrates. Moreover, triazoles attached with carbohydrates or amino acids are prepared via this cycloaddition.

Chemo- and Stereoselective Transition-Metal-Free Amination of Amides with Azides

The synthesis of α-amino carbonyl/carboxyl compounds is a contemporary challenge in organic synthesis. Herein, we present a stereoselective α-amination of amides employing simple azides that proceeds under mild conditions with release of nitrogen gas. The