823189-03-3

Basic information

• Product Name: Benzene, 1-(azidomethyl)-2-(trifluoromethyl)-
• CAS NO: 823189-03-3
• Molecular Formula: C8H6F3N3
• Molecular Weight: 201.151
• Mol File: 823189-03-3.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(azidomethyl)-2-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(azidomethyl)-2-(trifluoromethyl)-(823189-03-3)
• EPA Substance Registry System: Benzene, 1-(azidomethyl)-2-(trifluoromethyl)-(823189-03-3)

Safety Data

• Hazardous Substances Data: 823189-03-3(Hazardous Substances Data)

Upstream product

• 395-44-8 o-trifluoromethylbenzyl bromide 
• 4143-61-7 diethyl diazodicarboxylate 
• 346-06-5 (2-(trifluoromethyl)phenyl)methanol 

Downstream Products

• 2944-97-0 2-(trifluoromethyl)benzylamine hydrochloride 
• 3048-01-9 o-trifluoromethylbenzylamine 
• 1333143-42-2 C₂₇H₃₂F₃N₅O₄S 

Relevant articles and documents

NOVEL DIBENZOOXAPHOSPHININE OXIDE DERIVATIVE COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEGENERATIVE DISEASE COMPRISING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to a novel dibenzooxininin oxide derivative compound having various nitrogen-containing substituents introduced at 6-position of a dibenzooxaphosphorin oxide mononuclear, and to the use thereof. The present invention relates to a pharmaceutical composition for preventing or treating degenerative diseases and a health supplement food composition for preventing or treating degenerative diseases, comprising the dibenzooxaphosphorin oxide derivative compound of the present invention.

Discovery of a Series of Theophylline Derivatives Containing 1,2,3-Triazole for Treatment of Non-Small Cell Lung Cancer

Chemotherapy is the most common clinical treatment for non-small cell lung cancer (NSCLC), but low efficiency and high toxicity of current chemotherapy drugs limit their clinical application. Therefore, it is urgent to develop hypotoxic and efficient chemotherapy drugs. Theophylline, a natural compound, is safe and easy to get, and it can be used as a modified scaffold structure and hold huge potential for developing safe and efficient antitumor drugs. Herein, we linked theophylline with different azide compounds to synthesize a new type of 1,2,3-triazole ring-containing theophylline derivatives. We found that some theophylline1,2,3-triazole compounds showed a good tumor-suppressive efficacy. Especially, derivative d17 showed strong antiproliferative activity against a variety of cancer cells in vitro, including H460, A549, A2780, LOVO, MB-231, MCF-7, OVCAR3, SW480, and PC-9. It is worth noting that the two NSCLC cell lines H460 H and A549 are sensitive to compound d17 particularly, with IC50 of 5.929 ± 0.97?μM and 6.76 ± 0.25?μM, respectively. Compound d17 can significantly induce cell apoptosis by increasing the ratio of apoptotic protein Bax/Bcl-2 by downregulating the expression of phosphorylated Akt protein, and it has little toxicity to normal hepatocyte cells LO2 at therapeutic concentrations. These data indicate that these theophylline acetic acid-1,2,3-triazole derivatives may be potential drug candidates for anti-NSCLC and are worthy of further study.

An Autonomous Chemical Robot Discovers the Rules of Inorganic Coordination Chemistry without Prior Knowledge

We present a chemical discovery robot for the efficient and reliable discovery of supramolecular architectures through the exploration of a huge reaction space exceeding ten billion combinations. The system was designed to search for areas of reactivity f