823191-20-4Relevant academic research and scientific papers
3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: A novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors
Ranatunge, Ramani R.,Earl, Richard A.,Garvey, David S.,Janero, David R.,Letts, L. Gordon,Martino, Allison M.,Murty, Madhavi G.,Richardson, Stewart K.,Schwalb, David J.,Young, Delano V.,Zemtseva, Irina S.
, p. 6049 - 6052 (2004)
The synthesis of a series of novel 3-(2-methoxytetrahydrofuran-2-yl) pyrazoles and their in vitro cyclooxygenase-2 (COX-2) inhibitory activity in human whole blood (HWB) are reported. A series of 3-(2-methoxytetrahydrofuran-2- yl)pyrazoles (4-10) was synthesized. The compounds were evaluated for their ability to inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) activity in human whole blood (HWB). The compound, 5-(4-methanesulfonylphenyl)- 3-(2-methoxytetrahydrofuran-2-yl)-1-p-tolyl-1H-pyrazole 5 showed potent and selective COX-2 inhibition (IC50 for COX-1: >100 μM and COX-2: 1.2 μM).
