823195-13-7Relevant articles and documents
Design of bivalent ligands using hydrogen bond linkers: Synthesis and evaluation of inhibitors for human β-tryptase
Vaz, Roy J.,Gao, Zhongli,Pribish, James,Chen, Xin,Levell, Julian,Davis, Larry,Albert, Eva,Brollo, Maurice,Ugolini, Antonio,Cramer, Dona M.,Cairns, Jennifer,Sides, Keith,Liu, Feng,Kwong, Jennifer,Kang, Jiesheng,Rebello, Sam,Elliot, Michael,Lim, Hengkeang,Chellaraj, Vinolia,Singleton, Robert W.,Li, Yi
, p. 6053 - 6056 (2007/10/03)
Alternative to a covalent linker, hydrogen bonds can be used to link ligands for maintaining simultaneous interactions with multiple binding sites. This is exemplified by the synthesis and evaluation of amide derivatives as potent inhibitors of human β-tryptase. We exploit the concept of using hydrogen bonds to link multiple ligands for maintaining simultaneous interactions with polyvalent binding sites. This approach is demonstrated by the syntheses and evaluation of pseudo-bivalent ligands as potent inhibitors of human β-tryptase.