823201-92-9

Upstream product

• 26163-03-1 2-amino-3-bromo-5-chloropyridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 171774-38-2 N-(3-bromo-5-chloropyridin-2-yl)pyridin-1-ium-1-aminide 

Downstream Products

• 823201-97-4 N-(3-bromo-5-chloro-pyridin-2-yl)-4',N-dimethyl-benzenesulfonamide 
• 1029044-16-3 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine 

Relevant academic research and scientific papers

Exploratory Process Development of Pexidartinib through the Tandem Tsuji-Trost Reaction and Heck Coupling

A novel synthetic route to CSF1R inhibitor pexidartinib was designed and demonstrated. Crucial to the successful synthesis is a tandem Tsuji-Trost reaction and Heck coupling in combination with palladium and silver catalysis. The final product was obtained via five steps in 49percent yield with purity as high as 99.2percent. The cheap and available materials and reagents and easy operations for workup and purification make this route more practical.

Pyridinium N-2′-pyridylaminide: Synthesis of 3-aryl-2-aminopyridines through an intramolecular radical process

Tris(trimethylsilyl)silane (TTMSS) and azobisisobutironitrile (AIBN) promote the intramolecular heteroarylation of arenesulfonamides with pyridyl radicals under thermal conditions. The arenesulfonamides are easily prepared from pyridinium N-2′-pyridylamin