82333-40-2

Upstream product

• 81358-92-1 5-chloro-6-methoxy-4-methyl-8-nitroquinoline 
• 150-76-5 4-methoxy-phenol 
• 81358-81-8 4-methyl-5-hydroxy-6-methoxy-8-nitroquinoline 
• 64992-96-7 4-methyl-5,6-dimethoxy-8-nitroquinoline 

Downstream Products

• 82333-44-6 8-Amino-6-methoxy-5-(4-methoxyphenoxy)-4-methylquinoline 
• 98092-63-8 2-{4-[6-Methoxy-5-(4-methoxy-phenoxy)-4-methyl-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione 
• 80737-22-0 8-((4-Amino-1-methylbutyl)amino)-6-methoxy-5-(4-methoxyphenoxy)-4-methyl-quinoline 

Relevant academic research and scientific papers

Antimalarials. 14. 5-(Aryloxy)-4-methylprimaquine Analogues. A Highly Effective Series of Blood and Tissue Schizonticidal Agents

A series of five 5-(aryloxy)-4-methylprimaquine analogues has been prepared and evaluated for antimalarial activity.The compounds were tested for suppressive activity against Plasmodium berghei in mice and for radical curative activity against Plasmodium

4-Methyl-5-(unsubstituted and substituted phenoxy)-6-methoxy-8-(aminoalkylamino)quinolines

Compounds of the class including 4-methyl-5-(unsubstituted and substitutedhenoxy)-6-methoxy-8-(aminoalkylamino)quinolines as the free bases and pharmaceutically acceptable acid amine salts are described. The compounds are highly effective antimalarial agents which possess, surprisingly, both tissue schizonticidal (radical curative) and blood schizonticidal (suppressive) activity. In addition, these drugs have significantly better therapeutics indices than primaquine which is the current tissue schizonticidal drug of choice. Primaquine possesses no useful blood schizonticidal activity at tolerated dose levels.