82343-04-2Relevant articles and documents
Synthetic studies on coenzyme Q10: Part 31) - An improved C5 + C45 approach to the stereoselective synthesis of coenzyme Q10 via metal-halogen exchange strategy
Yu, Xiong-Jie,Dai, Hui-Fang,Chen, Fen-Er
, p. 967 - 971 (2008/02/04)
An efficient and stereoselective approach to the synthesis of coenzyme Q10 is described (Scheme). The MeOCH2-protected p-hydroquinone 4 containing the C5 (E)-allyl (tert-butyl) dimethylsilyl ether moiety was obtained via a halogen-lithium exchange of the MeOCH2-proctected 2-bromo-5,6-dimethoxy-3-methylhydroquinone 2 and subsequent addition to (E)-(tBuMe2Si)-OCH 2C(Me)= CHCH2Br (3). The reductive desulfonylation of compound 8, obtained from 4 via 5-7, was successfully carried out by employing Li/EtNH2.
An Efficient Stereoselective Synthesis of Co-enzyme Q10
Sato, Kikumasa,Miyamoto, Osamu,Inoue, Seiichi,Yamamoto, Tomoya,Hirasawa, Yukihiko
, p. 153 - 154 (2007/10/02)
Co-enzyme Q10 was efficiently synthesised by stereo- and regio-selective prenylation of the protected hydroquinone (2) with isoprene epoxide and solanesyl p-tolyl sulphone in a good overall yield.