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Usage

Uses

Used in Pharmaceutical Industry:
2-Thiazolol is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique chemical properties that facilitate the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Thiazolol serves as a vital component in the production of pesticides and other agrochemicals, leveraging its chemical structure to enhance the effectiveness of these products in protecting crops.
Used in Perfume Industry:
2-Thiazolol is utilized as a fragrance ingredient in the perfume industry, where its distinct aromatic properties contribute to the creation of unique and complex scents.
Used as a Corrosion Inhibitor:
2-Thiazolol is employed as a corrosion inhibitor in various industrial applications, protecting metals from degradation and extending the lifespan of equipment and structures.
Used as a Flavor Enhancer in the Food Industry:
In the food industry, 2-Thiazolol is used to enhance the flavor of certain products, adding depth and complexity to the taste profiles of various food items.
Used in Antimicrobial and Antifungal Applications:
Leveraging its antimicrobial and antifungal properties, 2-Thiazolol is a common ingredient in antibacterial and antifungal drugs, contributing to the prevention and treatment of infections caused by microorganisms.

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 113411-24-8 thiazole-2-sulfonamide 

Relevant academic research and scientific papers

Sterically constrained 'roofed' 2-thiazolidinones as excellent chiral auxiliaries

The 'roofed' chiral 2-thiazolidinones, which are sterically congested and conformational rigid, and which are prepared by the [4 + 2] cycloaddition of 2-thiazolone to the cyclic dienes, dimethylanthracene and hexamethylcyclopentadiene, followed by optical

Highly stereoselective formal synthesis of rosuvastatin and pitavastatin through Julia-Kocienski olefination using the lactonized statin side-chain precursor

An expedient and simple synthetic approach to pitava statin and rosuvastatin final intermediates is described. The presented approach consists of completely stereoselective Julia-Kocienski olefination step (E/Z up to 300:1) between lactonized statin side-chain precursor and sulfone derivative of the corresponding pyrimidine and quinoline heterocyclic cores. The desired O-TBS protected statin lactones were isolated in 66-71% yield and high >97% purity (HPLC). Georg Thieme Verlag Stuttgart. New York.

Hydroxylamine as an oxygen nucleophile: Substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides

Benzothiazole-2-sulfonamides react with an excess of hydroxylamine in aqueous solutions to form 2-hydroxybenzothiazole, sulfur dioxide, and the corresponding amine. Mechanistic studies that employ a combination of structure-reactivity relationships, oxygen labeling experiments, and (in)direct detection of intermediates and products reveal that the reaction proceeds via oxygen attack, and that oxygen incorporated in the 2-hydroxybenzothiazole product derives from hydroxylamine. The reaction, which is performed under mild conditions, can be used as a deprotection method for cleavage of benzothiazole-2-sulfonyl-protected amino acids.