82358-07-4

Basic information

• Product Name: 2-Thiazolol
• Synonyms: 2-Thiazolol;1,3-thiazol-2-ol;Thiazol-2-ol;3H-1,3-thiazol-2-one
• CAS NO: 82358-07-4
• Molecular Formula: C3H3NOS
• Molecular Weight: 101.13
• Mol File: 82358-07-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 251.0±23.0 °C(Predicted)
• Appearance: /
• Density: 1.433±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.01±0.10(Predicted)
• CAS DataBase Reference: 2-Thiazolol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolol(82358-07-4)
• EPA Substance Registry System: 2-Thiazolol(82358-07-4)

Safety Data

• Hazardous Substances Data: 82358-07-4(Hazardous Substances Data)

Usage

General Description

2-Thiazolol, also known as thiazole, is a five-membered aromatic compound with a nitrogen and sulfur atom in the ring. It is a colorless liquid with a strong and unpleasant odor. 2-Thiazolol is widely used in the synthesis of pharmaceuticals, agrochemicals, and perfumes. It is also used as a corrosion inhibitor and as a flavor enhancer in the food industry. In addition, 2-Thiazolol has antimicrobial and antifungal properties, which makes it a common ingredient in antibacterial and antifungal drugs. It is considered to be a versatile chemical with a wide range of industrial applications.

Upstream product

• 113411-24-8 thiazole-2-sulfonamide 
• 3034-53-5 2-bromo-1,3-thiazole 

Relevant articles and documents

Sterically constrained 'roofed' 2-thiazolidinones as excellent chiral auxiliaries

The 'roofed' chiral 2-thiazolidinones, which are sterically congested and conformational rigid, and which are prepared by the [4 + 2] cycloaddition of 2-thiazolone to the cyclic dienes, dimethylanthracene and hexamethylcyclopentadiene, followed by optical

Hydroxylamine as an oxygen nucleophile: Substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides

Benzothiazole-2-sulfonamides react with an excess of hydroxylamine in aqueous solutions to form 2-hydroxybenzothiazole, sulfur dioxide, and the corresponding amine. Mechanistic studies that employ a combination of structure-reactivity relationships, oxygen labeling experiments, and (in)direct detection of intermediates and products reveal that the reaction proceeds via oxygen attack, and that oxygen incorporated in the 2-hydroxybenzothiazole product derives from hydroxylamine. The reaction, which is performed under mild conditions, can be used as a deprotection method for cleavage of benzothiazole-2-sulfonyl-protected amino acids.