82359-88-4Relevant academic research and scientific papers
TRANSAMIDATION REACTIONS USING β-LACTAMS. THE SYNTHESIS OF HOMALINE
Wasserman, Harry H.,Berger, Gregory D.,Cho, Kathleen R.
, p. 465 - 468 (1982)
The synthesis of the plant product, homaline, by a translactamization process involving the β-lactam, (-)-4-phenyl-2-azetidinone, is described.
THE USE OF β-LACTAMS IN THE SYNTHESIS OF SPERMINE AND SPERMIDINE ALKALOIDS. TOTAL SYNTHESIS OF HOMALINE
Wasserman, Harry H.,Berger, Gregory D.
, p. 2459 - 2464 (2007/10/02)
The optically active plant product homaline (6) has been synthesized in a convergent sequence starting with β-phenyl-β-alanine and putrescine (14).The key transformation in this sequence is the ring expansion by transamidation of a functionalized chiral β-lactam precursor.
