82379-41-7Relevant articles and documents
Isolation, Synthesis, and Radical-Scavenging Activity of Rhodomelin A, a Ureidobromophenol from the Marine Red Alga Rhodomela confervoides
Li, Ke,Wang, Ya-Fei,Li, Xiao-Ming,Wang, Wei-Jia,Ai, Xu-Ze,Li, Xin,Yang, Sui-Qun,Gloer, James B.,Wang, Bin-Gui,Xu, Tao
, p. 417 - 420 (2018)
A novel ureidobromophenol, rhodomelin A (1), was characterized from Rhodomela confervoides. Its structure was elucidated by spectroscopic analysis. Both enantiomers of 1 were synthesized using a convergent strategy starting from d/l-pyroglutamic acids, respectively, allowing assignment of the R-configuration for the naturally occurring isomer by chiral HPLC analysis. Rhodomelin A represents the first example of a naturally occurring ureidopyrrolidone alkaloid incorporating a γ-aminobutyric acid unit. The scavenging activity of 1 toward DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate)) radicals was assayed.