82398-34-3

Basic information

• Product Name: Diaquo[(1R,2R)-1,2-cyclohexanediaMine]platinuM DiMer Dinitrate
• Synonyms: Diaquo[(1R,2R)-1,2-cyclohexanediaMine]platinuM DiMer Dinitrate;Oxaliplatin Impurity E
• CAS NO: 82398-34-3
• Molecular Formula: C₁₂H₃₀N₄O₂Pt₂*2NO₃
• Molecular Weight: 646.50056
• Product Categories: Amines;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 82398-34-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility: Methanol (Slightly), Water (Slightly)
• Stability: Light Sensitive
• CAS DataBase Reference: Diaquo[(1R,2R)-1,2-cyclohexanediaMine]platinuM DiMer Dinitrate(CAS DataBase Reference)
• NIST Chemistry Reference: Diaquo[(1R,2R)-1,2-cyclohexanediaMine]platinuM DiMer Dinitrate(82398-34-3)
• EPA Substance Registry System: Diaquo[(1R,2R)-1,2-cyclohexanediaMine]platinuM DiMer Dinitrate(82398-34-3)

Safety Data

• Hazardous Substances Data: 82398-34-3(Hazardous Substances Data)

Usage

Uses

A dimeric impurity of Oxaliplatin (O845075) with neoplasm-inhibiting activity.

Relevant articles and documents

Syntheses, Kinetics, and Mechanism of Formation of Polynuclear Hydroxo-Bridged Complexes of (trans-1,2-Diaminocyclohexane)platinum(II)

The synthesis and 195Pt chemical shifts of the hydroxo-bridged dimer and trimer, isolated from an aquated solution of bis(nitrato)(trans-1,2-diaminocyclohexane)platinum (I), at different pH are described.The chemical shifts of these three complexes are widely separated, and 195Pt NMR provides a convenient method for the investigation of dimer formation kinetics from I.Rate constants for the dimerization reaction calculated at different pD, temperature, and concentration agree well with the hypothesis that dimerization occurs with a rate-limiting bimolecular reaction of an intermediate hydroxo species formed by the loss of a proton from the parent complex.