82412-15-5

Basic information

• Product Name: 7-anilinocoumarin-4-acetic acid
• Synonyms: 7-anilinocoumarin-4-acetic acid
• CAS NO: 82412-15-5
• Molecular Formula: C₁₇H₁₃NO₄
• Molecular Weight: 295.29
• Mol File: 82412-15-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 545.5°C at 760 mmHg
• Flash Point: 283.7°C
• Appearance: /
• Density: 1.384g/cm³
• Vapor Pressure: 9.84E-13mmHg at 25°C
• Refractive Index: 1.673
• PKA: 4.22 ± 0.10, most acidic, temperature: 25 °C; -1.59 ± 0.20, most basic(at 25℃)
• CAS DataBase Reference: 7-anilinocoumarin-4-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-anilinocoumarin-4-acetic acid(82412-15-5)
• EPA Substance Registry System: 7-anilinocoumarin-4-acetic acid(82412-15-5)

Safety Data

• Hazardous Substances Data: 82412-15-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H13NO4/c19-16(20)8-11-9-17(21)22-15-10-13(6-7-14(11)15)18-12-4-2-1-3-5-12/h1-7,9-10,18H,8H2,(H,19,20)

Upstream product

• 82412-18-8 ethyl (7-anilino-2-oxo-2H-chromen-4-yl)acetate 
• 5526-36-3 3-oxo-glutaric acid monoethyl ester 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 101-18-8 3-hydroxy-N-phenylaniline 

Downstream Products

• 812653-50-2 N-[2-(3-benzoxy-2-methyl-4-oxopyridin-1(4H)-yl)ethyl]-2-(7-anilino-2-oxo-2H-chromen-4-yl)acetamide 
• 1025939-91-6 4-[2-oxo-2-(2-thioxo-thiazolidin-3-yl)-ethyl]-7-phenylamino-chromen-2-one 

Relevant articles and documents

Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors

The synthesis of a range of novel 3-hydroxypyridin-4-ones and 3-hydroxypyran-4-ones linked with different coumarin substituents is described. These compounds have been developed in order to provide a series of molecular probes for the quantification of intracellular labile iron pools. An evaluation of the effect of iron(III) on fluorescence intensity was undertaken. Chelation of iron(III) causes quenching of fluorescence. The relationship between iron(III) concentration and the extent of fluorescence quenching indicates that the metal is chelated in a complex with a metal-to-ligand stoichiometry of 1:3. The fluorescence of hydroxypyridinone compounds was found to be more efficiently quenched by iron(III) than were the hydroxypyranones. The metal-to-ligand stoichiometry at which maximum quenching is observed was found to depend on the site at which coumarin is attached. The efficiency of fluorescence quenching by iron(III) is markedly influenced by solvent polarity and pH. The permeability of two representative fluorescent chelators across human erythrocyte ghost membranes was investigated. The rate of permeability for a series of probes was found to be related to the corresponding ClogP values.