82414-33-3

Basic information

• Product Name: 2-oxo-2,3-dihydroindole-1-carboxylic acid ethyl ester
• Synonyms: 2-oxo-2,3-dihydroindole-1-carboxylic acid ethyl ester
• CAS NO: 82414-33-3
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205
• Mol File: 82414-33-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-oxo-2,3-dihydroindole-1-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-2,3-dihydroindole-1-carboxylic acid ethyl ester(82414-33-3)
• EPA Substance Registry System: 2-oxo-2,3-dihydroindole-1-carboxylic acid ethyl ester(82414-33-3)

Safety Data

• Hazardous Substances Data: 82414-33-3(Hazardous Substances Data)

Upstream product

• 59-48-3 2-oxoindole 
• 541-41-3 chloroformic acid ethyl ester 
• 91-56-5 indole-2,3-dione 
• 301700-12-9 2-ethoxycarbonyloxy-indole-1-carboxylic acid ethyl ester 
• 82414-30-0 C₂₅H₂₁N₃O₄ 

Downstream Products

• 880263-71-8 2-(4-isopropoxy-phenyl)-indole-1-carboxylic acid ethyl ester 
• 880263-74-1 (E)-ethyl 2-(4-methylstyryl)-1H-indole-1-carboxylate 
• 880263-77-4 (E)-ethyl 2-(2-cyclohexylvinyl)-1H-indole-1-carboxylate 
• 58995-80-5 2-(4-isopropoxyphenyl)-1H-indole 
• 1579957-13-3 C₃₁H₂₇NO₇ 

Relevant articles and documents

Enantioselective C2-Alkylation of Indoles through a Redox-Relay Heck Reaction of 2-Indole Triflates

A palladium-catalyzed enantioselective redox-relay Heck reaction of 2-indole triflates and disubstituted alkenes is reported. This process combines readily available indole triflates with a variety of alkenes to afford a range of indole derivatives bearing a stereocenter adjacent to C2. Enantioselectivity is achieved through use of a simple pyridine-oxazoline ligand. Tuning the electronics of the indole, through judicious choice of N-protecting group, is required to ensure selective β-hydride elimination away from the indole core. Utility of this method is highlighted in a modular formal synthesis of an S1P1 agonist precursor developed by Merck.

2-Trifluoromethanesulfonyloxyindole-1-carboxylic acid ethyl ester: A practical intermediate for the synthesis of 2-carbosubstituted indoles

Ready accessible 2-trifluoromethanesulfonyloxyindole-1-carboxylic acid ethyl ester undergoes palladium-catalyzed coupling reactions with different partners giving rise to 2-aryl, heteroaryl, vinyl, allyl, and alkynyl indoles in good to excellent yields. G

Synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles

Two protocols have been developed for the synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles starting from the corresponding N,O-diacyl derivatives obtained by treatment of 2-oxindoles with chloroformic acid esters and triethylamine. Th