82424-92-8

Upstream product

• 82424-59-7 4-amino-3-(4-chloro-phenyl)-isothiazole-5-carboxylic acid methyl ester 

Downstream Products

• 1410806-42-6 2-chloro-1-[3-(4-chloro-phenyl)-isothiazol-5-yl]-ethanone 
• 1410806-82-4 2-chloro-1-[3-(4-chloro-phenyl)-isothiazol-5-yl]-ethanone 

Relevant academic research and scientific papers

PROTEOSTASIS REGULATORS

The present invention is directed to compounds having the Formulae (Ia-Ie), (II), (IIIa-IIId), (IVa-IVc), (Va-Vb), (VIa-VIe), (VII), (VIIIa-VIIIc), and (IX), pharmaceutically acceptable salts, prodrugs and solvates thereof, compositions of any of thereof and methods for the treatment of a condition associated with a dysfunction in proteostasis comprising an effective amount of these compounds.

3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels

3-Phenyl (or meta or para-substituted phenyl)-4-permissibly substituted-5-isothiazolecarboxylic acids, salts, esters and simple amides, used to lower uric acid levels in mammals.