82436-18-8

Usage

General Description

1,3-Dithiolane, 2-(m-Tolyl)- is a chemical compound that is also known as 2-(3-methylphenyl)-1,3-dithiolane. It is a sulfur-containing heterocyclic compound with a five-membered ring containing two sulfur atoms and one oxygen atom. 1,3-DITHIOLANE, 2-(m-TOLYL)- is used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It is also used as a chiral auxiliary in asymmetric synthesis reactions. Additionally, it is used in the production of fragrances and flavoring agents due to its unique aromatic properties. Overall, 1,3-Dithiolane, 2-(m-Tolyl)- is a versatile compound with a wide range of applications in the field of organic chemistry.

InChI:InChI=1/C10H12S2/c1-8-3-2-4-9(7-8)10-11-5-6-12-10/h2-4,7,10H,5-6H2,1H3

Upstream product

• 540-63-6 ethane-1,2-dithiol 
• 620-23-5 m-tolyl aldehyde 
• 99-04-7 m-Toluic acid 

Downstream Products

• 3335-34-0 3-Methylbenzotrichloride 
• 620-23-5 m-tolyl aldehyde 

Relevant academic research and scientific papers

Indium-Catalyzed Reductive Dithioacetalization of Carboxylic Acids with Dithiols: Scope, Limitations, and Application to Oxidative Desulfurization

In this study an InI3-TMDS (1,1,3,3-tetramethyldisiloxane) reducing system effectively catalyzed the reductive dithioacetalization of a variety of aromatic and aliphatic carboxylic acids with 1,2-ethanedithiol or 1,3-propanedithiol leading to the one-pot preparation of either 1,3-dithiolane derivatives or a 1,3-dithiane derivative. Also, the intact indium catalyst continuously catalyzed the subsequent oxidative desulfurization of an in situ formed 1,3-dithiolane derivative, which led to the preparation of the corresponding aldehydes.

One-pot two-step conversion of aromatic carboxylic acids and esters to aromatic aldehydes via indium-catalyzed reductive thioacetalization and desulfurization

Described herein is that a new approach to a one-pot two-step conversion of aromatic carboxylic acids/esters to aromatic aldehydes, in which indium(III) iodide effectively catalyzes both the first reductive thioacetalization of carboxylic acids and a subsequent desulfurization of the in-situ formed thioacetal intermediates leading to aldehydes.

A mild method for the protection of aldehydes as dithioacetals and dithiolanes catalyzed by I2 generated in situ using Fe(NO 3)3.9H2O/Nai under heterogeneous conditions

Structurally diverse aromatic aldehydes were thioacetalated in a clean and efficient reaction with ethane-1,2-dithiol and thiophenol based on the use of I2 generated in situ from Fe(NO3)3.9H 2O/NaI. The reaction occurs in good to high yield in dichloromethane at room temperature and the use of toxic and corrosive molecular iodine is avoided.

Trichloromelamine (TCM) - Catalyzed efficient and selective thioacetalization of aldehydes and transthioacetalization of acetals and oxathioacetals under mild reaction conditions

Trichloromelamine was used effectively as a catalyst for thioacetalization of aldehydes and transthioacetalization of acetals and oxathioacetals under mild and almost neutral reaction conditions. By this method, aldehydes, acetals, and oxathioacetals were selectively protected in the presence of ketones as their 1,3-dithiolanes or 1,3-dithianes. Copyright Taylor & Francis Group, LLC.

Tungsten hexachloride (WCl6) as an efficient catalyst for chemoselective dithioacetalization of carbonyl compounds and transthioacetalization of acetals

A variety of aldehydes, ketones and O,O-acetals were efficiently converted to the corresponding 1,3-dithianes and 1,3-dithiolanes by using catalytic amounts of tungsten hexachloride (WCl6) in CH2Cl2 under mild conditions.

Process for preparing substituted benzotrichlorides

The invention herein pertains to a novel process for making substituted benzotrifluorides.

Comparative radioprotective activity of various pentagonal compounds with two heteroatomes

Various heterocyclic compounds with two heteroatomes were synthesized and their potential radioprotective activity was tested. This study shows the interest of phenylthiazolidines derivatives in chemical radioprotection.