82436-77-9

Usage

Uses

Used in Biochemistry Research:
Bis(sulfosuccinimidyl)suberate is used as a protein cross-linker for the study of protein-protein interactions, receptor-ligand binding, and the investigation of protein structure and function. Its water solubility and ability to form stable cross-links make it a valuable tool in biochemical research.
Used in Immunology:
In immunology, Bis(sulfosuccinimidyl)suberate is used as a cross-linking agent for the cross-linking and targeting of mouse erythrocytes. This allows researchers to study the immune response and the interaction between erythrocytes and immune cells.
Used in Drug Development:
Bis(sulfosuccinimidyl)suberate is used as a cross-linking agent in the development of protein-based drugs. It is used to cross-link growth factors to proteinase inhibitors, enhancing the stability and efficacy of the drug.
Used in Analytical Chemistry:
In analytical chemistry, Bis(sulfosuccinimidyl)suberate is used for the preparation of protein-protein, receptor-ligand, and hapten-carrier molecule conjugates. This allows for the development of sensitive and specific assays for the detection and quantification of various molecules.
Used in Materials Science:
Bis(sulfosuccinimidyl)suberate is used as a cross-linking agent in the development of new materials with specific properties. For example, it can be used to cross-link calveolin proteins, which may have potential applications in the development of new materials with unique properties.
Overall, Bis(sulfosuccinimidyl)suberate is a versatile protein cross-linker with a wide range of applications in various fields, including biochemistry research, immunology, drug development, analytical chemistry, and materials science. Its ability to form stable cross-links between proteins and other molecules makes it a valuable tool for advancing scientific knowledge and developing new technologies.

InChI:InChI=1/C16H20N2O14S2/c19-11-7-9(33(25,26)27)15(23)17(11)31-13(21)5-3-1-2-4-6-14(22)32-18-12(20)8-10(16(18)24)34(28,29)30/h9-10H,1-8H2,(H,25,26,27)(H,28,29,30)

Relevant academic research and scientific papers

DLL3-TARGETING MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF

The disclosure provides multispecific antigen-binding molecules that comprise a first antigen-binding moiety and a second antigen-binding moiety, each of which is capable of binding to CD3 and CD137, but does not bind to CD3 and CD137 at the same time; and a third antigen-binding moiety that is capable of binding to DLL3, preferably human DLL3, which induce T-cell dependent cytotoxity more efficiently whilst circumventing adverse toxicity concerns or side effects that other multispecific antigen-binding molecules may have. The present invention provides multispecific antigen-binding molecules and pharmaceutical compositions that can treat various cancers, especially those associated with DLL3, by comprising the antigen-binding molecule as an active ingredient.

NON-HUMAN ANIMAL HAVING HUMAN CD3 GENE SUBSTITUTED FOR ENDOGENOUS CD3 GENE

The present invention provides genetically modified non-human animals which are deficient in at least one or more types of CD3 genes selected from the group consisting of endogenous CD3ε, CD3δ, and CD3γ in its genome and functionally express at least one or more types of human CD3 genes selected from the group consisting of human CD3?, CD3δ, and CD3γ. In the genetically modified non-human animals of the present invention, mature T cell differentiation and production can take place, and immunocompetent cells including T cells can exert their functions. The genetically modified non-human animals of the present invention enable efficient evaluation and screening in the development of therapeutic agents and therapeutic methods that use human CD3-mediated targeted drugs.