824431-48-3

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 501374-30-7 5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane 
• 455-13-0 4-Iodobenzotrifluoride 

Downstream Products

• 1613582-55-0 (2S,3R)-N-(4-toluenesulfonyl)-2-(4-trifluoromethylphenyl)-3-(phenylthio)piperidine 
• 1613582-42-5 (E)-N-(4-toluenesulfonyl)-5-(4-trifluoromethylphenyl)pent-4-enylamine 
• 1613582-41-4 C₁₃H₁₅F₃O₃S 
• 1334150-02-5 (2R,3S)-tetrahydro-3-(phenylthio)-2-(4-(trifluoromethyl)phenyl)-2H-pyran 
• 824431-60-9 2,2-Dimethyl-5-((E)-5-phenyl-pent-4-enyl)-5-[(E)-5-(4-trifluoromethyl-phenyl)-pent-4-enyl]-[1,3]dioxane-4,6-dione 
• 824431-58-5 (6E)-2-[(4E)-5-phenylpent-4-enyl]-7-(p-trifluoromethylphenyl)hept-6-enoic acid 
• 1027266-67-6 (E)-2-((E)-5-Phenyl-pent-4-enyl)-7-(4-trifluoromethyl-phenyl)-hept-6-enoyl chloride 
• 824431-59-6 1-((E)-5-iodopent-1-enyl)-4-trifluorotoluene 

Relevant academic research and scientific papers

Catalytic Hydroetherification of Unactivated Alkenes Enabled by Proton-Coupled Electron Transfer

We report a catalytic, light-driven method for the intramolecular hydroetherification of unactivated alkenols to furnish cyclic ether products. These reactions occur under visible-light irradiation in the presence of an IrIII-based photoredox catalyst, a Br?nsted base catalyst, and a hydrogen-atom transfer (HAT) co-catalyst. Reactive alkoxy radicals are proposed as key intermediates, generated by direct homolytic activation of alcohol O?H bonds through a proton-coupled electron-transfer mechanism. This method exhibits a broad substrate scope and high functional-group tolerance, and it accommodates a diverse range of alkene substitution patterns. Results demonstrating the extension of this catalytic system to carboetherification reactions are also presented.

Nickel-catalyzed ring-opening cross-coupling of cyclic alkenyl ethers with arylboronic esters via carbon-oxygen bond cleavage

We have developed a nickel-catalyzed cross-coupling reaction of cyclic alkenyl ethers with arylboronic esters that leads to the formation of unsaturated alcohols via ring-opening by the cleavage of a C(sp2)-O bond. The use of 1,3-dicyclohexylimidazol-2-ylidene as the ligand is essential to promote this cross-coupling process.

Enantioselective bromocycloetherification by Lewis base/chiral Bronsted acid cooperative catalysis

A binary catalyst system for the enantioselective bromocycloetherification of 5-arylpentenols is described. The combination of an achiral Lewis base and a chiral Bronsted acid affords good enantioselectivities for the cyclization of Z configured 5-arylpen

Competition between alkenes in intramolecular ketene-alkene [2 + 2] cycloaddition: What does it take to win?

(Chemical Equation Presented). In the course of developing a new synthetic methodology using ketenes in sequential cycloaddition steps, we were faced with a competition problem with molecules containing a ketene tethered to more than one reacting partner.