82447-61-8

Basic information

• Product Name: 1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-amine
• Synonyms: 1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-amine
• CAS NO: 82447-61-8
• Molecular Formula: C10H10BrN3
• Molecular Weight: 252.1105
• Mol File: 82447-61-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-amine(82447-61-8)
• EPA Substance Registry System: 1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-amine(82447-61-8)

Safety Data

• Hazardous Substances Data: 82447-61-8(Hazardous Substances Data)

Upstream product

• 2469-99-0 Cyanoaceton 
• 622-88-8 4-bromophenylhydrazine hydrochloride 
• 1118-61-2 3-Aminocrotononitrile 
• 589-21-9 (4-bromophenyl)hydrazine 

Relevant articles and documents

Oxidative Ring-Opening of 1H-Pyrazol-5-amines and Its Application in Constructing Pyrazolo–Pyrrolo–Pyrazine Scaffolds by Domino Cyclization

Herein, an oxidative ring-opening of 1H-pyrazol-5-amines to form 3-diazenylacrylonitrile derivatives under mild and transition-metal-free conditions is described. In addition, the nucleophilic addition of deprotonated 1H-pyrrole-2-carbaldehydes to the vinyl moiety of the yielded 3-diazenylacrylonitriles could trigger domino cyclization to afford the 3H-pyrazolo[3,4-e]pyrrolo[1,2-a]pyrazine derivatives. Computational studies suggest that the oxidation of 1H-pyrazol-5-amines in the presence of PhIO is through the formation of a hydroxylamine intermediate followed by elimination of H2O to result in the ring-opening product. The detailed domino cyclization pathway leading to the pyrazolo–pyrrolo–pyrazine scaffolds is revealed.

Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles

The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline-pyrrolidine/pyrrolothiazole/indolizine-oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo[3,4-b]quinoline derivatives.